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ID:32373566
大小:3.03 MB
页数:63页
时间:2019-02-03
《一体化管盖基因芯片检测系统(光学与控制)研制》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、AbstractThemicroarraytechnique,ahigh—throughputdetectionmethod,hasbeenwidelyapplied.ThecoretechniqueinvolvedingenearraysisthereverseoftheSouthernblottechnique.Themicroarrayprogressisquiteeasytocauseunstableresultbecauseofitscomplexprocessandmultistage.Themicroarray-in-a-tubesystemisaseale
2、dsystemforthemicroarraytechnique.Inthesystem,anoligonucleotidemicroarrayisarrangedontheinnersurfaceofaspecialdesignedofEppendorfcap、析thaflatopticallytransparentwindow.Aninnervesselforthestorageofthehybridizationsolutionisplacedinthesealtube.Themicroarraysystemsimplifythecomplexityandperfo
3、rmnonecontaminationmicroarraydetectionbecauseoftheencapsulatedsystem.However,commercialdetectionsystemisn’tsuitableforthemicroarraydetectionsystem,becaussethemicroarray-in-a-tubeisastrangedevicecomparedwiththestandardglassmicroarrayslide.Asaresult,adetectionsystemwithanopticalsystem,allau
4、tomaticscanningsystemhasbeendevelopedforthemicroarray-in—a-tubedetectioninthelaboratory.TheopticalsystemWasdevelopedbymeansoffluorescencemicroscopeandNikonD90camera.LaserWasselectedasilluminationsourceandalaserbeamexpansion&energyhomogenizationsystemWasdesigned.Automaticscanningsystemcons
5、istsofacontrolcircuitanda3-Dmobileplatformtoperformscandetectionofmultimicroarray-in—a—tubes.TMS320F2812DigitalSignalProcessorwhichishighlyintegrated,high—performancesolutionsfordemandingcontrolapplicationsWasselectedashostcontrollerinthecircuit,TheCypressSemiconductorCY7C68013A-128isused
6、8.SusbinterfacechiptodealswimcommunicationbetweenPCandF2812inthesystem.The3-Dmobileplatform’Stransmissionmechanismconsistsofballserews,linearguidetracksandslides.Testresultsindicatethattheopticalsystemandautomaticscanningsystemarecapableofsatisfydetectionrequirements.Comparetootherchipsca
7、nner,advantagesofourdetectionsystemaremuchevident,foritislow-cost,small—size,lowpower,portableandeasytooperate.KEYWORDS:microarray;fluorescenceimagingdetection;electroniccontrol;mobileplatformII目录摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯IAbstract⋯⋯⋯⋯⋯⋯⋯⋯
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