trpv1在急性宫颈扩张所致的内脏痛中的作用与机制

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1、万方数据浙江大学硕士学位论文英文摘要TheroleofTransientReceptorPotentialVanilloidtype1inpaininducedbyuterinecervicaldistensioninratsZhejiangUniversitySchoolofMedicineAnesthesiologyBackground：Postgraduate：CuicuiJIAOSupervisor：XinzhongCHENAbstractLaborpain，akindofphysicallyvisceralpain，isoneofthemostseri

2、ouspainthatwomenexpierencedintheirlives．In2700casesofmaternalobservationalstudieshaveshownthat85％ofwomenthinkthepainexperiencesmoderatetosevereduringlabor．Thedrasticpaininlaborcanproduceaseriesofadverseeffectsonmaternalandfetal．Somoreandmorepatientsfocusonhowtoallievateandcurethelabo

3、rpain．，Althoughtherearelotsofresearchesaboutthelaborpain，itsmechanismisstillunkown．Thepainofthefirststageoflabororiginateintheloweruterinesegmentanduterinecervix，akindtypicallyacutevisceralpain．Theuterinecervix，whichalIlinvolvedinthewholeparturition，isthevicseralsensitiveareasandthei

4、nnervationfromuterinecervixismostabundantinthefemalegenitaltract．Fromtheabove，uterinecervicaldistentionisthemainsitewherepaininlaborarises．Researcheshaveshownthatthespinalcordisthecentralpartofpaintransmission，alsotheneurotransmitterandtheproteinchannelsisvitalforUStounderstandlaborp

5、aininthespinalcordlevel．Recently,theV万方数据浙江大学硕士学位论文英文摘要relatedstudiesDetectedthatTRPVlchannelhasanexpressioninuterinecervix．TRPVlisanimportantmembranereceptorandCanmediateorintegrateallkindsofharmfulstimulus．TRPV1Canbeactivatedbyinflammatorymediators，thenproducesthenociceptivesignals

6、．SomeresearchesreferredthattheapplicationofTI冲V1channelblockersCancausepainsensitizationbyestrogen，whichsuggeststhatTRPVlmayparticipateintheformationofthelaborpain，butmathasnotfurtherconfirmed．objection：ToobservedifferentlevelsofdistensionontheinfluenceofTRPV1expressioninthespinalcor

7、d，andanalysesitsroleandmechanisminacuteuterinecervicaldistension．MaterialsandMethod：Atotalof54adultfemalevirginSprague-Dawleyratsweighing220—250g，purchasedfromShanghaiSlacLaboratoryAnimalCo．Ltd．，Shanghai，China，wereused．Food，butnotwater,waswithheldfor8hbeforethestudy．Animalswereanesth

8、etizedwiminh