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ID:32289326
大小:7.66 MB
页数:52页
时间:2019-02-02
《hifu对兔vx2乳腺癌杀伤效应及超声造影显示乳腺癌前哨淋巴结的实验的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、重庆医科大学硕士研究生学位论文HIFU对兔VX2乳腺癌杀伤效应及超声造影显示乳腺癌前哨淋巴结的实验研究摘要1.HIFU对兔YX2乳腺癌杀伤效应目的:探讨高强度聚焦超声(HighIntensityFocusedUltrasound,HIFU)对兔VX2乳腺癌微血管密度(microvesseldensity,MVD)、微淋巴管密度(1ymphaticmicrovesseldensity,LMVD)和增殖细胞核抗原表达(proliferatingcellnuclearantigen,PCNA)的影响。方法:将兔VX2乳腺癌模型30只,随机分为对照组5只,H
2、IFU治疗组25只。分别于治疗前、治疗后第3天进行彩色多普勒血流显像(CDFI)和超声造影(CEUS)检查,分析HIFU治疗前后瘤体血流灌注变化情况。通过免疫组化染色检测肿瘤组织MVD、LMVD及PCNA的表达。结果:HIFU治疗后,CDFI在靶区未测及任何彩色血流信号;CEUS检查发现21只兔子的肿瘤组织无造影剂充盈,4只发现线性回声增强。在显微镜400倍视野下观察,HIFU组MVD平均为2.3+0.56个,LMVD平均为1.7+0.78,PCNA阳性率为0,与对照组MVD、LMVD、PCNA比较差异有统计学意义(尸3、完全杀死乳腺癌癌细胞和破坏肿瘤转移途径,达到治愈乳腺癌的效果。2重庆医科大学硕士研究生学位论文2.超声造影显示乳腺癌前哨淋巴结目的:通过与亚甲蓝(Methyleneblue,MB)示踪法比较,探讨超声造影检测乳腺癌前哨淋巴结(sentinellymphnode,SLN)的前景。方法:建立兔VX2乳腺癌模型24只,皮下注射SonoVue,超声造影显像SLN,观察其造影增强情况;再经皮下注射MB示踪;行腋窝淋巴结清扫术切除SLN并行AEl/AE3免疫组化染色。结果:24只瘤兔超声造影检出回声均匀性增强的SLN12个,回声不均匀性增强和部分充盈缺损的SLN4、22个;MB示踪法检出SLN32个;术中腋窝淋巴结清扫SLN38个。以手术切除的SLN免疫组化结果为标准,超声造影的检出率(89.47%)、敏感性(95.24%)与MB示踪法检出率(84.21%)、敏感性(91.30%)比较无显著差异(P>O.05);但其特异性(84.62%)和准确性(91.18%)均明显高于MB示踪法的特异性(26.67%)和准确性(65.79%)(尸5、超声造影,前哨淋巴结,杀伤效应3重庆医科大学硕士研究生学位论文EXPERIMENTALSTUDYOFDAMAGEEFFECToFHIGHINTENSITYFoCUSEDULTRASoUNDTREATMENToNVX2IⅣⅡ,LANTEDBREASTCANCERINRABBITANDEXPERIMENTALSTUDYoFDETECTIoNoFUIJRASoUNDCONTRASTTRACERoNTHESENTINELUIfrM咿HNoDEINRABBITWITHVX2IMPLANTEDBREASTCANCERABSTRACTPARTONE"Experim6、entalstudyofdamageeffectofhighintensityfocusedultrasoundtreatmentonVX2implantedbreastcancel"inrabbitObjective:ToexplorethedamageeffectofHIFUonmicrovesseldensity(MVD),lymphaticmicrovesseldensity(LMVD)andproliferatingcellnuclearantigenexpression(PCNA)inVX2implantedbreastcancerinr7、abbit.Methods:Atotalof30femaleNewzealandrabbitswithmammaryimplantationofVX2carcinomasweredividedintotwogroups,withfiveinthecontrolgroup,twenty—fiveunderwentHIFUtreatment.ColorDopplerflowimaging(CDFI)andcontrastenhancedultrasonography(CEUS)wereperformedbeforeandthreedaysafterHIF8、Utreatment,respectively.MVDandLMVDandPCNAwereexaminedw
3、完全杀死乳腺癌癌细胞和破坏肿瘤转移途径,达到治愈乳腺癌的效果。2重庆医科大学硕士研究生学位论文2.超声造影显示乳腺癌前哨淋巴结目的:通过与亚甲蓝(Methyleneblue,MB)示踪法比较,探讨超声造影检测乳腺癌前哨淋巴结(sentinellymphnode,SLN)的前景。方法:建立兔VX2乳腺癌模型24只,皮下注射SonoVue,超声造影显像SLN,观察其造影增强情况;再经皮下注射MB示踪;行腋窝淋巴结清扫术切除SLN并行AEl/AE3免疫组化染色。结果:24只瘤兔超声造影检出回声均匀性增强的SLN12个,回声不均匀性增强和部分充盈缺损的SLN
4、22个;MB示踪法检出SLN32个;术中腋窝淋巴结清扫SLN38个。以手术切除的SLN免疫组化结果为标准,超声造影的检出率(89.47%)、敏感性(95.24%)与MB示踪法检出率(84.21%)、敏感性(91.30%)比较无显著差异(P>O.05);但其特异性(84.62%)和准确性(91.18%)均明显高于MB示踪法的特异性(26.67%)和准确性(65.79%)(尸5、超声造影,前哨淋巴结,杀伤效应3重庆医科大学硕士研究生学位论文EXPERIMENTALSTUDYOFDAMAGEEFFECToFHIGHINTENSITYFoCUSEDULTRASoUNDTREATMENToNVX2IⅣⅡ,LANTEDBREASTCANCERINRABBITANDEXPERIMENTALSTUDYoFDETECTIoNoFUIJRASoUNDCONTRASTTRACERoNTHESENTINELUIfrM咿HNoDEINRABBITWITHVX2IMPLANTEDBREASTCANCERABSTRACTPARTONE"Experim6、entalstudyofdamageeffectofhighintensityfocusedultrasoundtreatmentonVX2implantedbreastcancel"inrabbitObjective:ToexplorethedamageeffectofHIFUonmicrovesseldensity(MVD),lymphaticmicrovesseldensity(LMVD)andproliferatingcellnuclearantigenexpression(PCNA)inVX2implantedbreastcancerinr7、abbit.Methods:Atotalof30femaleNewzealandrabbitswithmammaryimplantationofVX2carcinomasweredividedintotwogroups,withfiveinthecontrolgroup,twenty—fiveunderwentHIFUtreatment.ColorDopplerflowimaging(CDFI)andcontrastenhancedultrasonography(CEUS)wereperformedbeforeandthreedaysafterHIF8、Utreatment,respectively.MVDandLMVDandPCNAwereexaminedw
5、超声造影,前哨淋巴结,杀伤效应3重庆医科大学硕士研究生学位论文EXPERIMENTALSTUDYOFDAMAGEEFFECToFHIGHINTENSITYFoCUSEDULTRASoUNDTREATMENToNVX2IⅣⅡ,LANTEDBREASTCANCERINRABBITANDEXPERIMENTALSTUDYoFDETECTIoNoFUIJRASoUNDCONTRASTTRACERoNTHESENTINELUIfrM咿HNoDEINRABBITWITHVX2IMPLANTEDBREASTCANCERABSTRACTPARTONE"Experim
6、entalstudyofdamageeffectofhighintensityfocusedultrasoundtreatmentonVX2implantedbreastcancel"inrabbitObjective:ToexplorethedamageeffectofHIFUonmicrovesseldensity(MVD),lymphaticmicrovesseldensity(LMVD)andproliferatingcellnuclearantigenexpression(PCNA)inVX2implantedbreastcancerinr
7、abbit.Methods:Atotalof30femaleNewzealandrabbitswithmammaryimplantationofVX2carcinomasweredividedintotwogroups,withfiveinthecontrolgroup,twenty—fiveunderwentHIFUtreatment.ColorDopplerflowimaging(CDFI)andcontrastenhancedultrasonography(CEUS)wereperformedbeforeandthreedaysafterHIF
8、Utreatment,respectively.MVDandLMVDandPCNAwereexaminedw
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