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ID:32288301
大小:3.95 MB
页数:30页
时间:2019-02-02
《fascin和mvd的表达和垂体腺瘤侵袭性的关系》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、山西医科大学硕士学位论文Fascin和MVD的表达与垂体腺瘤侵袭性的关系中文摘要目的检测Fascin及MVD在侵袭性和非侵袭性垂体腺瘤中的表达,探讨其与垂体腺瘤侵袭性的关系及它们之间的相关性。方法1.选取垂体腺瘤手术标本45例(包括侵袭性垂体腺瘤24例和非侵袭性垂体腺瘤21例)。全部组织经10%福尔马林固定,常规脱水后石蜡包埋,连续切片。2.采用免疫组化Envision法检测Fascin在侵袭性垂体腺瘤、非侵袭性垂体腺瘤中的表达水平,测定垂体腺瘤组织MVD。3.统计学分析两组之间Fasicn蛋白的表达、MVD计数的差异,以及侵袭性垂体腺瘤中Fascin
2、的表达与MVD计数之间的相关关系。结果1.在24例侵袭性垂体腺瘤中,Fascin阳性表达18例,占75.0%,而在21例非侵袭性垂体腺瘤中Fascin表达阳性者为9例,占42.9%,两组比较,有显著性差异(χ2=4.821,P=0.028)。2.MVD计数,在侵袭性垂体腺瘤中为42.27±8.04,在非侵袭性垂体腺瘤中为30.31±6.16,经统计学分析有明显差异(t=5.539,p=0.000)。3.经统计学分析,侵袭性垂体腺瘤中Fascin的表达水平均与MVD计数呈正相关(r=0.713,p=0.000)。结论1.与非侵袭性垂体腺瘤组相比,Fasc
3、in在侵袭性垂体腺瘤中均有高表达,提示侵袭性垂体腺瘤的生物学行为与Fascin的高表达有关。2.侵袭性垂体腺瘤组中MVD计数明显高于非侵袭性垂体腺瘤组,提示垂体腺瘤的侵袭性与血管生成密切相关。3.侵袭性垂体腺瘤组工Fascin的表达均与垂体腺瘤中MVD计数成正相关,提示Fascin可能通过促进肿瘤的微血管生长来促进肿瘤的生长、侵袭甚至转移。关键词:垂体腺瘤,Fascin,MVD,侵袭性I山西医科大学硕士学位论文ExpressionoffascinandcorrelateswiththeinvasionofpituitaryadenomaAbstract
4、ObjectiveToinvestigatetheexpressionofFascinandMVDinpatientswithinvasiveandnon-invasivepituitaryadenomas,andtoevaluatetherelationshipbetweentheexpressionofFascin,CD34andtheinvasionofpituitaryadenomas,andtoanalyzethecorrelationbetweenFascinandMVDininvasivepituitaryadenomas.Methods
5、145surgicallyresectedpituitaryadenomasamples,including24invasivepituitaryadenomasand21non-invasivepituitaryadenomas.Allofthetissueswerefixedin10%neutralformalinandembeddedinparaffin.2EnvisionimmunostainingtechniquewasusedtodetectFascinandMVDinallofthetissues.3Analyzethedifferenc
6、esoftheexpressionofFascinandCD34betweentheinvasiveandnon-invasivepituitaryadenomas,andthecorrelationbetweenFascinandMVDininvasivepituitaryadenomasbythestatistiealmethodResults1ThepositiveexpressionrateofFascinininvasivepituitaryadenomasandnon-invasivepituitaryadenomasis75.0%,42.
7、9%respectively.Thereissignificantdifferencebetween2groups(χ2=4.821P=0.028).2ThereissignificantdifferenceofmeanvalueofMVDbetweeninvasivepituitaryadenomasgroup(42.27±8.04)andnon-invasiveadenomasgroup(30.31±6.16)(t=5.539,p=0.000).3ThereispositivecorrelationbetweenFascinexpressionan
8、dMVDininvasivepituitaryadenomasgroup(r=0.713,p=
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