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ID:32255333
大小:3.67 MB
页数:54页
时间:2019-02-02
《dsg3和肺癌预后相关性的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、天津医科大学硕士学位论文中文摘要目的1.探讨ds93在非小细胞肺癌(NSCLC)和类癌中的表达情况以及其与患者年龄、性别、肿瘤大小、临床病理分期和肿瘤分化程度的关系;2.探讨ds93的表达与NSCLC及类癌预后之间的关系。方法1.对天津市胸科医院胸外科2002年1月.2004年8月期间手术治疗的肺癌患者进行电话回访,取得详细随访结果的为58例NSCLC和12例类癌患者,利用K.M法计算其3年、5年生存率,并对其临床和病理资料进行分析。2.应用免疫组化法检测58例NSCLC和12例类癌组织中Ds93的表达水平和分部情况。3.分析Ds93在肺癌各组织类型间表达的差异及其与患者性
2、别、年龄、肿瘤大小、临床病理分期和肿瘤分化程度之间的关系。4.分析鳞癌、腺癌和类癌患者的术后生存时间与Ds93表达的关系。结果1.本组患者的平均术后生存时间为37.24士18.46月。利用Kaplan.Meier法计算得3年、5年生存率分别为60.34%、43.75%。2.Ds93表达阳性组3年、5年生存率高于表达阴性组患者(P3、著差异。3.Ds93的表达与性别、年龄、肿瘤临床病理分期等特征没有相关性(P>O.05)。4.Ds93的表达与肿瘤的病理类型、分化程度有相关性(P<0.05),分化程度高组阳性表达高于分化程度低组。结论1.Ds93在肺癌组织中的表达与否可以作为肺癌预后的一个指标,阳性表达提示预后较好。2.Ds93的表达与肿瘤组织的病理类型和癌细胞分化程度的高低有相关性。天津医科大学硕十学位论文关键词:桥粒芯糖蛋白3非小细胞肺癌预后免疫组化II天津医科大学硕士学位论文objectiveAbstract1.Toinvestigatetheexpressionofds93innon-smallc4、elllungcancerandcarcinoid,andtodiscussthereferenceofds93withthesize,staging,differentiationofthetumortissueandgender,ageofthepatient.2.Toinvestigatetherelationshipofds93andthe3-year,5-yearsurvivalrateoflungcancer,thesurvivaltimeaftersurgeryofSCC,ADcarcinoidandtheexpressionofds93.Methods1.T5、ofollowupthesurgerypatientsoftianjinchesthospitalbetweenJan,2002andAug,2004bytelephone.58non-smallcelllungcancerpatientsand12caricinoidpatientswereobtainedasanoutcome,and3-yearsurvival,5-yearsurvivalWasalsoobtainedaccordingKeplan-Meier.Thecilinicalandpathologicaldataswerealsogiven.2.Theexp6、ressionconditionofds93Wasdetectedinthe58NSCLCtissuesand12carcinoidtissuesbyimmunohistochemicalmethod.3.Analyzetheexpressiondifferenceofds93ineachkindofNSCLC,discussiontherelationshipofthecilinicalcharacteristic(gender,age)ofthepatientsandsize,staging,differentiationofthetumors.4.Analyzethe7、referenceofds93and3-yearsurvival,5-yearsurvivalofthepatients.AnalyzethesurvivaltimeaftersurgeryofSCC,ADcarcinoidandtheexpressionofds93.Results1.TheaverageStWasobtainedas37.24+18.46months,andthe3-yearsurvival,5-yearsurvivalWas60.34%and43.75%byKaplan-Meier.2.The
3、著差异。3.Ds93的表达与性别、年龄、肿瘤临床病理分期等特征没有相关性(P>O.05)。4.Ds93的表达与肿瘤的病理类型、分化程度有相关性(P<0.05),分化程度高组阳性表达高于分化程度低组。结论1.Ds93在肺癌组织中的表达与否可以作为肺癌预后的一个指标,阳性表达提示预后较好。2.Ds93的表达与肿瘤组织的病理类型和癌细胞分化程度的高低有相关性。天津医科大学硕十学位论文关键词:桥粒芯糖蛋白3非小细胞肺癌预后免疫组化II天津医科大学硕士学位论文objectiveAbstract1.Toinvestigatetheexpressionofds93innon-smallc
4、elllungcancerandcarcinoid,andtodiscussthereferenceofds93withthesize,staging,differentiationofthetumortissueandgender,ageofthepatient.2.Toinvestigatetherelationshipofds93andthe3-year,5-yearsurvivalrateoflungcancer,thesurvivaltimeaftersurgeryofSCC,ADcarcinoidandtheexpressionofds93.Methods1.T
5、ofollowupthesurgerypatientsoftianjinchesthospitalbetweenJan,2002andAug,2004bytelephone.58non-smallcelllungcancerpatientsand12caricinoidpatientswereobtainedasanoutcome,and3-yearsurvival,5-yearsurvivalWasalsoobtainedaccordingKeplan-Meier.Thecilinicalandpathologicaldataswerealsogiven.2.Theexp
6、ressionconditionofds93Wasdetectedinthe58NSCLCtissuesand12carcinoidtissuesbyimmunohistochemicalmethod.3.Analyzetheexpressiondifferenceofds93ineachkindofNSCLC,discussiontherelationshipofthecilinicalcharacteristic(gender,age)ofthepatientsandsize,staging,differentiationofthetumors.4.Analyzethe
7、referenceofds93and3-yearsurvival,5-yearsurvivalofthepatients.AnalyzethesurvivaltimeaftersurgeryofSCC,ADcarcinoidandtheexpressionofds93.Results1.TheaverageStWasobtainedas37.24+18.46months,andthe3-yearsurvival,5-yearsurvivalWas60.34%and43.75%byKaplan-Meier.2.The
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