iga肾病患者肾组织与尿液ctgf的表达与意义

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1、IgAnephropathyinpatients耐threnaltissueandudneExpressionandsignificanceofCTGFAbstractBackground：IgAnephopathyis血ewodd’smostcommon弭omerulonephrids协priInary哲omermonephrids访Chjnaaccountedfor20％一30％，themost卯icalpatholo百calchangesarefocalordifmsemesan垂ummesan百alceⅡsandmesan西almatr仅incfeaseintubuloi

2、ntersddallesions谢thfocalmblllaratrophy，inflammatoryceUinmtradonandmtersd血l曲rosisseenthusagainstrenal肪rosisint11eprotecdonofrenal凡nc石onhasbecome山efocusoftreatment【1】．Iknalintersddalflbrosisischaracterizedbynormalrenaltubularstructureandhasbeengatheringala培en咖berofexl=racellularmatr政replacedbyt

3、hedssuerepairmechaflismthatis出edarkside．Ala喀enumberofstudieshaVeshownthatrenalintersddalfibrosisandrenalfuncdonofthedegreeofcorreladonthant11e酉omerularsderosisandren甜funclionismorecloselyrelated．NowwidelyrecognizedthatTGF—13inthepathogenesisofrenaJ胁rosisplaysan曲portantroleinblo出ngTGF—pifthesy

4、stemis出epreVendonandtrea廿nentofrenaJ丘brosiSinmemostef&c西陀wayofhope．H叭陀ver，becauseTGF—13ef先ctsmaddidontopromodng6brosis，thereareand—inflanljrnatory，and—tumorandimrImnesuppression，suchasbi010殍calef&cts，itcompletelyblockedthelon手termmayleadtoout_of．con廿．olcengro、础，immunedisorders，inflanljrnadona

5、ndotherserioussideef琵cts【2】．CTGFistheTGF—pacd访哆inthelowerreachesofDesmoplasdcmedias迢palcanbeme出atedbyTGF—p—inducedsdnluladonofceⅡprohferadonandeXtraceUmarmatrix(exctraceUularma血，EC峋formadon，m血elddneyplaysanimportantroleifl6brosis，andbiolo酉calef&cts山anasin寸e，becamethecurrentPrevendonofrenalfib

6、rosisresearchanewhotspot，butalsoforthetrea乜nentofIgAnephropathy、词lproVidenewideas，andtmspaperusedforthe缸st血neu血aryCTGFdetecdontOdeter曲etheIgAnephropathy血t11etubulomters6daldiseasesimadon，acertaindegreeofinnoVadon．objectil咒：1'oCTGFin出eurineofpadents耐山I酚nephropathyandrenaldssuedistribudonofchll

7、icaln-ea廿nentforIgAnephropatllytopro访deasciend丘cbasis．Mcthods：January2008toJuly，ourpadentcoⅡected56casesofprirnaryIgAnephropal．hyudnespecirIlens，urinespecimensre面ssioninurinaryproteillnegative(2、)l陀eks，3timesthenormalurine)coⅡected．Detecdonof