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ID:28567280
大小:11.01 MB
页数:58页
时间:2018-12-11
《hif1α vegf在不明原因反复自然流产患者绒毛组织中的表达及与mvd的关系》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、兰州大学硕士学位论文原因之一。4)HIF一1仅、VEGF与MVD的相关关系的研究,有望为URSA的预防和治疗提供有力的理论依据。关键词:不明原因反复自然流产缺氧诱导因子.1a血管内皮生长因子微血管密度II兰州大学硕士学位论文ABSTRACTObjecive:ToexaminetheexpressionofHIF一1aandVEGFinvillusofpatientswithunexplainedrecurrentspontaneousabortion(URSA),andtostudyitsrelationwithMVD.ThentodetecttheeffectofhypoxiaandHIF
2、—laontheexpressionofVEGFintheconditionalculturedcyto仃ophoblastswouldprovideguidanceforthestudyofthepathogenesisofURSA.Method:ImmunohistochemicalSPmethodwasusedtoexaminetheexpressionofHIF—la,ⅦGFandMVDinvillusof28URSApatientsand20heaithypregnantwomen.TheresultWasanalyzedbySPSSl1.5.Result:1)Villiedema
3、cytotrophoblastcellhyperplasiaandsyncytiotrophoblastcelldecreasewereobservedinthecasegroup.Cytotrophoblastedgesharpness,cellularnuclesvascuolar,syncytiotrophoblastcomparativelylargetoconfluenceoneanotherwereobservedinthecontrolgroup.2)HIF-laandVEGFwere.observedchieflyinplasmaandmembranceof.cytotrop
4、hoblastscellandvascularendothelialcellbotllinthetwogroups.Andthemesenchymalhaslittlestain.HowevertheexpressiondegreeofHIF-1aandVEGFinthevilliofthecasegroupweredecreasedsignificantlythanthatofthecontrolgroup.3)Angiodysplasia,luminanarrowornoapparentelumina,littlebloodcellintheluminaofthecasegroup,th
5、everageofMVDWassignificantdecreasedinthecasegroupthanthatofthecontrolgroup.4)PositivecorrelationWasfoundbetweenHIF一1aandVEGEPositivecorrelationWasfoundbetweenHIF.10【、VEGFandⅣⅣD.Conclusion:1)Comparedtothevilliofnormalpregnant,therewererecessivechangsinthevillioftheURSA.2)HIF—laandVEGFexpressionofthe
6、villusmayplayanimportantroleinthenormalpregnant,possiblythroughaffectingthecytotrophoblasticinvasionandplacentalvascularreconstructionviathemodulationofVEGFgenetranscription.3)TheexpressionlevelsofHIF一1sandVEGFinvilluswerelowerinIRSAgroup111兰州大学硕士学位论文thanthoseincontrol,andthevilluswereangiodysplasi
7、a.ItwasindicatethatHIF—lacanregulateVEGFbyresumingtheoxygenpressure.ThesewouldresulttheURSA.4)neresesrchoftheexpressionofHIF-1Ⅱ,VEGFandMVDinvilliandthecorrelationbetweenthemmightoffertheoryproofforpreventio
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