hif1α vegf在不明原因反复自然流产患者绒毛组织中的表达及与mvd的关系

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1、兰州大学硕士学位论文原因之一。4)HIF一1仅、VEGF与MVD的相关关系的研究，有望为URSA的预防和治疗提供有力的理论依据。关键词：不明原因反复自然流产缺氧诱导因子．1a血管内皮生长因子微血管密度II兰州大学硕士学位论文ABSTRACTObjecive：ToexaminetheexpressionofHIF一1aandVEGFinvillusofpatientswithunexplainedrecurrentspontaneousabortion(URSA)，andtostudyitsrelationwithMVD．ThentodetecttheeffectofhypoxiaandHIF

2、—laontheexpressionofVEGFintheconditionalculturedcyto仃ophoblastswouldprovideguidanceforthestudyofthepathogenesisofURSA．Method：ImmunohistochemicalSPmethodwasusedtoexaminetheexpressionofHIF—la，ⅦGFandMVDinvillusof28URSApatientsand20heaithypregnantwomen．TheresultWasanalyzedbySPSSl1．5．Result：1)Villiedema

3、cytotrophoblastcellhyperplasiaandsyncytiotrophoblastcelldecreasewereobservedinthecasegroup．Cytotrophoblastedgesharpness，cellularnuclesvascuolar,syncytiotrophoblastcomparativelylargetoconfluenceoneanotherwereobservedinthecontrolgroup．2)HIF-laandVEGFwere．observedchieflyinplasmaandmembranceof．cytotrop

4、hoblastscellandvascularendothelialcellbotllinthetwogroups．Andthemesenchymalhaslittlestain．HowevertheexpressiondegreeofHIF-1aandVEGFinthevilliofthecasegroupweredecreasedsignificantlythanthatofthecontrolgroup．3)Angiodysplasia,luminanarrowornoapparentelumina,littlebloodcellintheluminaofthecasegroup，th

5、everageofMVDWassignificantdecreasedinthecasegroupthanthatofthecontrolgroup．4)PositivecorrelationWasfoundbetweenHIF一1aandVEGEPositivecorrelationWasfoundbetweenHIF．10【、VEGFandⅣⅣD．Conclusion：1)Comparedtothevilliofnormalpregnant，therewererecessivechangsinthevillioftheURSA．2)HIF—laandVEGFexpressionofthe

6、villusmayplayanimportantroleinthenormalpregnant，possiblythroughaffectingthecytotrophoblasticinvasionandplacentalvascularreconstructionviathemodulationofVEGFgenetranscription．3)TheexpressionlevelsofHIF一1sandVEGFinvilluswerelowerinIRSAgroup111兰州大学硕士学位论文thanthoseincontrol，andthevilluswereangiodysplasi

7、a．ItwasindicatethatHIF—lacanregulateVEGFbyresumingtheoxygenpressure．ThesewouldresulttheURSA．4)neresesrchoftheexpressionofHIF-1Ⅱ，VEGFandMVDinvilliandthecorrelationbetweenthemmightoffertheoryproofforpreventio