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1、中文摘要目的:本文主要通过清肺化痰逐瘀汤对中医辨证属痰瘀互结的AECOPD患者的临床观察,观察其对AECOPD患者MMP-9、C-反应蛋白(CRP)的影响,评价清肺化痰逐瘀汤对AECOPD患者的临床疗效,为进一步临床治疗提供依据。方法:将具有可比性的60例中医辨证属痰瘀互结的AECOPD患者随机分为2组,对照组30例,给予控制性氧疗,头孢他啶(对头孢他啶过敏者选用氨曲南,或阿奇霉素)配合喹诺酮类药(如左氧氟沙星)抗感染;喘息者给予茶碱类药,痰稠不易咯出者予以沐舒坦;治疗组30例,除上述西医治疗外,配合清肺化痰逐瘀汤治疗,观察两组患者临床症状、体征、血、尿常规、肝肾功
2、能、胸片或CT、心电图、肺功能等一般检测及MMP-9、CRP的影响,疗程均为14天,一个疗程之后,就其临床疗效和安全性作出评估。结果:符合纳入标准的慢性阻塞性肺疾病急性加重期证属痰瘀互结的两组患者,在治疗前无显著差异的前提下,治疗组经加用肺化痰逐瘀汤治疗后,该组患者咳嗽、咯痰、胸闷、喘息、气短有明显差异(P<0.05),舌下静脉迂曲、颜面口唇紫绀总积分有显著性差异(P<0.01),说明治疗组症状、体征改善优于对照组,治疗组与对照组MMP-9、CRP指标治疗前后均差异显著(P<0.05)。就肺功能来讲,其治疗前后指标相比无统计学意义。但就统计数值显示,治疗组和对照组F
3、EV1、FEV1%都呈轻度上升趋势,且治疗组上升趋势要大些。结论:临床观察结果显示:清肺化痰逐瘀汤能够明显减轻AECOPD患者的临床症状、体征,显著降低血清中MMP-9、CRP值,能有效改善肺功能,提高通气功能。关键词:AECOPD;清肺泄热;降气化痰;通腑泄浊;化瘀通络;MMP-9;CRP;肺功能;清肺化痰逐瘀汤TheClinicialEffectResearchandInfluenceandMeaningstoMMP-9andCRPoftheQingfeiPhlegmDecoctiontoAECOPDAbstractObjective:Thisarticlema
4、inlythroughQingfeiPhlegmDecoctiononTCMisphlegmintheclinicalobservationofpatientswithAECOPDwereobservedontheAECOPDpatientsMMP-9,C-reactiveprotein(CRP)toevaluatetheeffectofAECOPDQingfeiPhlegmDecoctionclinicalefficacy,providethebasisforfurtherclinicaltreatment.Method:60patientswithcompara
5、bleTCMisphlegmintheAECOPDpatientswererandomlydividedinto2groups,controlgroupof30patientsreceivedcontrolledoxygentherapy,ceftazidime(choosethosewhoareallergictoceftazidimeandaztreonam,orazithromycin)withquinolones(ofloxacinlefthandside)anti-infective;wheezingweregiventheophyllinedrugs,t
6、hickphlegmspitupandwhoisnoteasytoambroxol;treatmentgroup30cases,inadditiontotheWesterntreatment,treatingwithQingfeiPhlegmDecoctionwereobservedclinicalsymptoms,signs,twoconventional(blood,urine),liverandkidneyfunction,chestX-rayorCT,ECG,lungfunctionandothergeneraltestingandMMP-9,CRPeffe
7、ctsoftreatmentlasted14days,acourseAfteritsclinicalefficacyandsafetyassessment.Results:mettheinclusioncriteriaofchronicobstructivepulmonarydiseasewithacuteexacerbationofcardsisphlegminthetwogroupsofpatients,beforetherapy,nosignificantdifferenceinthepremise,thetreatmentgroupaftertreatm