婴儿巨细胞病毒肝炎的病毒载量与t淋巴细胞亚群及nk细胞的关系

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1、授予单位代码10089学号或申请号16211中国图书分类号R392.11.硕士研究生论文学术学位婴儿巨细胞病毒肝炎的病毒载量与T淋巴细胞亚群及NK细胞的关系研究生：周艳导师：宋淑霞教授专业：免疫学二级学院：基础医学院2018年3月目录中文摘要················································································1英文摘要································································

2、················4英文缩写················································································7研究论文婴儿巨细胞病毒肝炎的病毒载量与T淋巴细胞亚群及NK细胞的关系前言···············································································8材料与方法···············································

3、·······················10结果···············································································14附图···············································································16附表·············································································

4、··21讨论···············································································23结论···············································································26参考文献·········································································26综述HCMV感染及其诱导的特异性免疫应答特

5、征····················29致谢···················································································41个人简历···············································································42婴儿巨细胞病毒肝炎的病毒载量与T淋巴细胞亚群及NK细胞的关系摘要目的：人巨细胞病毒（Humancytomegalovirus,HCMV）属于疱疹病毒科

6、β亚科的DNA双螺旋状病毒，是疱疹病毒科中基因组最强大的病毒，其基因组可编码超过200多个病毒蛋白。HCMV是一种人类普遍易感的病原体，感染后病毒不能被彻底清除，而是以潜伏的形式存在，在我国约90%以上的人群存在HCMV的潜伏感染。它与人类一起进化了数千年，在潜伏期、免疫逃逸和传播方面有着错综复杂的平衡。当机体免疫机能发生改变后，会发生HCMV再激活，引发HCMV活动性感染。一般人群初次感染后没有明显症状，婴幼儿处于器官组织发育形成的重要时期，免疫系统尚未形成，极易感染巨细胞病毒。婴幼儿巨细胞病毒感染不但可以使生长发育迟缓，还可对呼吸

7、系统、消化及神经系统造成相应损害，引发各种临床症状，表现为肝炎、肺炎、听力损害、神经系统异常、血液系统疾++病等。参与HCMV感染的免疫细胞主要有CD4T细胞、CD8T细胞、NK细胞等。有资料显示6个月以下小婴儿易发生HCMV感染，肝胆系统是HCMV感染的主要靶器官，巨细胞病毒肝炎是临床上发病率较高的肝炎重症，对患儿的健康造成了较大的威胁。本研究通过选择我院就诊并诊断为巨细胞病毒（HCMV）活动性感染的小婴儿作为研究对象；分析1.巨细胞病毒肝炎患儿外周血T淋巴亚群及NK细胞的水平变化；2.巨细胞病毒肝炎患儿外周血HCMV-DNA载量与

8、T淋巴亚群、NK细胞数及肝功能的相关性。方法：选择2017年2月-2018年1月河北医科大学第二医院收治的HCMV活动性感染婴儿48例，年龄<1周岁。其中巨细胞病毒肝炎30例，中枢神经系统损伤5例，肺炎9例，血液系统疾患