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ID:20642251
大小:4.49 MB
页数:49页
时间:2018-10-14
《骨水泥及prolene网在犬骨性胸壁缺损模型修复与重建中的实验研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、TheexperimentalstudyofbonecementwithprolenenetintherepairandreconstructionofchestwalldefectindogmodelsAbstractObjectiveOnthebasisofscientificexperimentaldataobtained,weevaluatethephysicalcharacteristicofthebonecement,Prolenenetwithbonecement"sandwich"artificialcompositematerials.Wealsoevaluateadjace
2、nttissuethermaldamageofbonecementinducedbytheexothermicreactionintheprocessofrepairandreconstructionofthechestwall,andactivelyexplorethepreventionfromthethermaldamage.Methods1.Thecompressivestrengthtest:Accordingtotheclinicalapplicationofartificialmaterials,theexperimentwasdividedintothreegroups,nam
3、elypigbiologicalribgroup,bonecementribgroup,prolenenetwithbonecement“sandwich”compositeribgroup.Thegroupsweresubjectedtocompressivestrengthtests.2.Toevaluateexothermicreactiondamageofthebonecementforthetissueofexperimentalanimal,andevaluatetheeffectofhypothermicnormalsalineperfusiononpreventingtherm
4、alinjury.Accordingtotheexperimentalpurpose,4mongreldogswererandomlydividedintothermalinjurygroupandperfusionthermalinjuryprotectiongroup,afterthoracotomy.Inthechestwallandbilateralribsofthedogs,aartificiallargechestwalldefectmodelatthesizeof12cm×6cmwasmade.Twopiecesof15cm×15cmprolenenetswith60gbonec
5、ementinthe"sandwich"methodwasusedfortherepairandreconstructionforthechestwalldefectofexperimentaldogs.Thethicknessofbonecementprosthesischestwallwas10mm.Inthethermalinjurygroup,thedogs4万方数据didn'tnotacceptanyheatinjurypreventionmeasuresTopreventthethermaldamageofadjacenttissuesinducedbyexothermicreac
6、tionintheprocessofmouldingonecement,weconstructednormalsalineperfusioncirculationsystem,inwhichweutilized25℃normalsalinecontinuousperfusioncirculationataspeedof500mlperminutetomatchthecoolingeffect.Finally,muscletissuesamplesofthethermaldamagegroupandthermaldamageprotectiongroupwerestainedwithHEandp
7、hosphotungsticacidhaematoxylin.Theheatshockprotein70wasalsodetectedbyimmunohistochemistryandtransmissionelectronmicroscopic.3.Statisticalanalysis.ThedatawereanalyzedbySPSS18.0statisticalsoftware.Theme
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