资源描述：
《川崎病（kawasaki disease）课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、Kawasakidiseaseisararecondition.Itismostcommoninchildrenunderfiveyearsoldandmostcasesoccurinchildrenagedbetweenninemonthsandtwoyears.Casesoccurinallethnicorigins,itismorecommoninchildrenofAsianoriginandmorecommoninboysthangirls.OriginIn1967,aJapaneseallergist,ProfessorKawa
2、saki,firstdescribedanoutbreakofapeculiarillnessinyoungchildreninJapan.Oneofthepatientswashisson.Severalyearslater,afewoutbreakswerereportedinothercountriesandthedevelopmentofcoronaryvasculitiswerereported.Kawasakidiseaseoccursyear-round,butagreaternumberofcasesarereportedi
3、nthewinterandspring.AnnualincidenceratesintheUnitedStatesandCanadarangefromabout6to11casesper100,000childrenlessthanfiveyears,theincidenceratesinNorthAmericaarehighestinchildrenofAsianethnicity(especiallythoseofJapaneseorKoreanbackground).InJapan,theyearlyincidenceratewas9
4、0casesper100,000childrenlessthanfiveyears.Avarietyofinfectiousagentshavebeenproposed,however,anetiologicagenthasnotbeendocumented.TheimmunesystemisknowntobeinvolvedduringtheacutestageofKawasakidisease.Inresponsetoanunknowntriggeringprocess,markedimmunoregulatoryabnormaliti
5、esareobserved.Antibodiesmaythentargetthevascularendothelium,resultinginacascadeofeventsleadingtovasculardamage.Avarietyofinfectiousagentshavebeenproposed,however,anetiologicagenthasnotbeendocumented.TheimmunesystemisknowntobeinvolvedduringtheacutestageofKawasakidisease.Inr
6、esponsetoanunknowntriggeringprocess,markedimmunoregulatoryabnormalitiesareobserved.Antibodiesmaythentargetthevascularendothelium,resultinginacascadeofeventsleadingtovasculardamage.AcutephaseSubacutephaseConvalescentphaseAcutePhaseThefirstsetofsymptomscommonlylastupto10or11
7、days.Theyinclude:Suddenonsetoffever(hightemperature)ConjunctivitisChangesinthemouth:aredthroat,spottytongueorcrackedlipsAblotchypinkrashEnlargedlymphnodeintheneckSwellingandrednessofthehandsandfeetSubacutePhaseGradualsubsidingoffeverMarkedthrombChangesinthemouth:aredthroat
8、,spottytongueorcrackedlipsAblotchypinkrashEnlargedlymphnodeintheneckSwellingandrednessoft
