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1、KawasakiDisease:ABriefHistoryJaneC.Burns,MD;HowardI.Kushner,PhD³;JohnF.Bastian,MD§;HirokoShike,MD;ChisatoShimizu,MD;TomoyoMatsubara,MDi;andChristenaL.Turner,PhD¶ABSTRACT.TomisakuKawasakipublishedthefirstera.CasereportsofIPNfromWesternEuropeextendEnglish-lang
2、uagereportof50patientswithKawasakibacktoatleastthe19thcentury,but,thusfar,casesofdisease(KD)in1974.Sincethattime,KDhasbecometheIPNhavenotbeendiscoveredinJapanbeforeWorldWarleadingcauseofacquiredheartdiseaseamongchildrenII.PerhapsthefactorsresponsibleforKDwer
3、eintro-inNorthAmericaandJapan.AlthoughaninfectiousducedintoJapanaftertheWorldWarIIandthenre-agentissuspected,thecauseremainsunknown.How-emergedinamorevirulentformthatsubsequentlyever,significantprogresshasbeenmadetowardunder-spreadthroughtheindustrializedWes
4、ternworld.Itisstandingthenaturalhistoryofthediseaseandtherapeu-alsopossiblethatimprovementsinhealthcareand,inticinterventionshavebeendevelopedthathalttheparticular,theuseofantibioticstotreatinfectionscausedimmune-mediateddestructionofthearterialwall.Webyorga
5、nismsincludingtoxin-producingbacteriare-presentabriefhistoryofKD,reviewprogressinresearchducedtheburdenofrash/feverillnessandallowedKDtoonthedisease,andsuggestavenuesforfuturestudy.berecognizedasadistinctclinicalentity.KawasakisawhisfirstcaseofKDinJanuary196
6、1andItsuzoShigematsu,HiroshiYanagawa,andcolleaguespublishedhisfirstreportinJapanesein1967.Whetherhaveconducted14nationwidesurveysinJapan.ThesecasesexistedinJapanbeforethattimeiscurrentlyunderhaveindicatedthat:1)KDoccurredinitiallyinnation-study.Themostsignif
7、icantcontroversyinthe1960sinwideepidemicsbutnowoccursinregionaloutbreaks;2)Japanwaswhethertherashandfeversign/symptomthereare;5000to6000newcaseseachyear;3)currentcomplexdescribedbyKawasakiwasconnectedtosub-estimatesofincidenceratesare120to150casespersequentc
8、ardiaccomplicationsinanumberofcases.Pa-100000children<5yearsold;4)KDis1.5timesmorethologistNoboruTanakaandpediatricianTakajirocommoninmalesand85%ofcasesoccurinchildren<5Yamamotodisputedtheearlya
