资源描述:
《糖尿病药物分类》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、糖尿病药物的分类按作用机制分类:常用口服抗糖尿病药物的分类1.促进胰岛β细胞分泌胰岛素的制剂磺脲类降糖药(SUs)餐时血糖调节剂(瑞格列奈、那格列奈)2.促进外周组织增加葡萄糖利用的药物双胍类(二甲双胍)3.抑制肠道葡萄糖吸收的药物α-糖苷酶抑制剂4.胰岛素增敏剂(TZDs)噻唑烷二酮类,双胍类1.1胰岛素促泌剂Ø通过作用于胰岛β细胞膜受体,促使胰岛素释放,从而产生降糖效果,ØSUsSU是治疗T2DM的主要药物之一。Ø餐时血糖调节剂新型降糖药----那格列奈、瑞格列奈1.1.1磺脲类药物的降糖机制Ø胰腺内作用机制:促使β细胞ATP敏感的钾离子通道关闭
2、,刺激胰腺β细胞释放胰岛素;Ø胰腺外作用机制:增加外周葡萄糖利用,第1、2代可能继发于葡萄糖毒性作用的改善。第三代亚莫利可增加胰岛素敏感性。couplingCentreshallbechecked,thesecondpouredconcretestrengthofmorethan70%.Intheprocessofreamingorboring,apartfromthespecialprovisionsinfactory,doesnotallowanyworkthatmayaffectthecouplingCentre,suchasirrigatio
3、n,tocylinderconnectionstofloodthecondenserpipesandsoon.Wellboring,hingeboltholeflangewithcouplingofvertical,notoblique.Mountingboltsshouldbeaddedlubricants,typinggentlywithasmallhammer,nottoolooseortootight,packedtheboltswiththecorrespondingsealscrewholeshouldbemarked.6.4.5.4.2
4、couplingreamedandpairingsisclosetothediameterofboltbearinggoodhingeholes,dressedwithagoodtwocouplingboltsbeforeyoucanmovetherotor,boring-reamingholeinturn.Couplingboltsmustbetightcouplingissymmetricaldiameter,inboring,reaming,twoboltsout.Wellboring,hingeboltholeflangewithcoupli
5、ngofvertical,notoblique.Duetothecouplingboltsinaccordancewithhingeholescorrespondingtothediameterofthescrewholesonebyoneafterprocessing,processingbackboltinstallationlocationcannotbechanged,soaccordingtoboltaftertheactualweightdifferenceofnutandlockwashertomatch.Generalrequirem
6、entsforcouplingtwosymmetricaldiameterbolt,nutandlockwasher'stotalweightdifferenceshouldnotbegreaterthan10gandknocksstampedmark.(SeeFigure18)Thecouplingboltsapplylubricant,andthengentlywithcopperhome,nottoolooseortootight.BoltAssemblyisfinished,symmetricaltighteningallboltsto30%
7、,50%,70%,100%force,andcheckthecouplingflutterandbeforeconnectingthecirclegraduallychangesitsvalueshouldbelessthan0.02mm.Tighteningtorqueofthecouplingboltsshallcomplywiththetechnicalrequirementsmanufacturersdrawings,withadynamometricwrenchorlogtensiontools.Threewheelrotorswingte
8、stcouplingconnectionsshouldbechecked:takingleave,1.1.2