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1、糖尿病药物的分类按作用机制分类：常用口服抗糖尿病药物的分类1.促进胰岛β细胞分泌胰岛素的制剂磺脲类降糖药（SUs）餐时血糖调节剂（瑞格列奈、那格列奈）2.促进外周组织增加葡萄糖利用的药物双胍类（二甲双胍）3.抑制肠道葡萄糖吸收的药物α-糖苷酶抑制剂4.胰岛素增敏剂（TZDs）噻唑烷二酮类，双胍类1.1胰岛素促泌剂Ø通过作用于胰岛β细胞膜受体，促使胰岛素释放，从而产生降糖效果，ØSUsSU是治疗T2DM的主要药物之一。Ø餐时血糖调节剂新型降糖药----那格列奈、瑞格列奈1.1.1磺脲类药物的降糖机制Ø胰腺内作用机制：促使β细胞ATP敏感的钾离子通道关闭，刺激胰腺β细胞释放胰岛素；Ø胰腺
2、外作用机制：增加外周葡萄糖利用，第1、2代可能继发于葡萄糖毒性作用的改善。第三代亚莫利可增加胰岛素敏感性。couplingCentreshallbechecked,thesecondpouredconcretestrengthofmorethan70%.Intheprocessofreamingorboring,apartfromthespecialprovisionsinfactory,doesnotallowanyworkthatmayaffectthecouplingCentre,suchasirrigation,tocylinderconnectionstofloodthec
3、ondenserpipesandsoon.Wellboring,hingeboltholeflangewithcouplingofvertical,notoblique.Mountingboltsshouldbeaddedlubricants,typinggentlywithasmallhammer,nottoolooseortootight,packedtheboltswiththecorrespondingsealscrewholeshouldbemarked.6.4.5.4.2couplingreamedandpairingsisclosetothediameterofbolt
4、bearinggoodhingeholes,dressedwithagoodtwocouplingboltsbeforeyoucanmovetherotor,boring-reamingholeinturn.Couplingboltsmustbetightcouplingissymmetricaldiameter,inboring,reaming,twoboltsout.Wellboring,hingeboltholeflangewithcouplingofvertical,notoblique.Duetothecouplingboltsinaccordancewithhingeho
5、lescorrespondingtothediameterofthescrewholesonebyoneafterprocessing,processingbackboltinstallationlocationcannotbechanged,soaccordingtoboltaftertheactualweightdifferenceofnutandlockwashertomatch.Generalrequirementsforcouplingtwosymmetricaldiameterbolt,nutandlockwasher'stotalweightdifferenceshou
6、ldnotbegreaterthan10gandknocksstampedmark.(SeeFigure18)Thecouplingboltsapplylubricant,andthengentlywithcopperhome,nottoolooseortootight.BoltAssemblyisfinished,symmetricaltighteningallboltsto30%,50%,70%,100%force,andcheckthecouplingflutterandbeforeconnectingthecirclegraduallychangesitsvalueshoul
7、dbelessthan0.02mm.Tighteningtorqueofthecouplingboltsshallcomplywiththetechnicalrequirementsmanufacturersdrawings,withadynamometricwrenchorlogtensiontools.Threewheelrotorswingtestcouplingconnectionsshouldbechecked:takingleave,1.1.2
