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时间:2018-09-15
《水溶性蜂胶颗粒对实验性2型糖尿病大鼠氧化应激与肝脏病变的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中罔养蜂学会蜜蜂产品专业委员会筇七次学术研讨会会议论文2006.11北京水溶性蜂胶颗粒对实验性2型糖尿病大鼠氧化应激与肝脏病变的影响胡福良¨,李雅晶2,陈民利3(1.浙江大学动物科学学院,杭州310029;2.浙江大学医学院,杭州310030;3.浙江中医药大学,杭州310053)摘要:采用动物实验法,观察不同剂量水溶性蜂胶对2型糖尿病大鼠窄腹m糖(FBG)、空腹血清胰岛素(F蹦s)、胰岛素作用指数(IAI),血清甘油三酯(1'G)、总胆同醇(TC)、高密度酯蛋白胆固醇(HDLC)、低密度酯蛋白胆同醇(LDL广C)、超氧化物歧化酶(SOD)、
2、丙二醛(MDA)、谷丙转胺酶(JuJ)、谷草转胺酶(AST)及肝脏病理学形态的影响。结果发现,水溶性蜂胶对2型糖尿病大鼠血清√uJ、AST、TC、HD【广C及LDL-C无显著影响,但各剂量水溶性蜂胶可显著降低2型糖尿病大鼠的FBG、TG及MDA(尸《o.01、P<0.05),提高IAI和sOD(P3、索抵抗Effectsofpropolis·beta-cyclodextringrainsonoxidativestressandDiabeticfattyliver(DFL)intype2diabetesmellitus(T2DM)ratsHUFu.1ian91,LIYa-jin92,CHENMin—li3(1.College巧AnimatSciences,ZjejiangUniversity,aangzhou310029,China;2.CollegeofMedicine,刁l嘶肌gUniversity,magzhOil310030,Chi4、na;3.Zhe#angTraditionalChineseMedicinalUniversity,Hangzhou310053,China)Abstract:Theeffectsofpropolis—beta-cyciodextringrainsonoxidativestressandDFLwereevaluatedbydeterminingthechangesoffastingbloodglucose(FaG),fastinginsulin(FINS),insulinactindex(IAI),triglycerides(TG),tota5、lcholesterol(TC),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL—C),superoxidedismutase(SOD),Malonaldehyde(MDA),AlanineAminotransferase(ALT),AspartateAminotransferage(AST)andliverpathologicalfeatures.Theresultsshowedthattherewerenosignificantdi6、fferenceexhibitedinLDL-Clevel,HDL.Clevel,Tc,ALTandASTlevelbetweenpropolis—beta-cyclodextringrainstreatmentgroupsandT2DMmodelcontrolgroup.Treatedwithpropolis—beta-cyclodextringrainscansignificantlydepresstheserumlevelofFBGandTG(P<0.01,P<0.05),decreasethecontentofMDA(P<0.01,P7、<0.05),andimproveIAIandSOD(P<0.05),comparedwithmodelcontrolgroup.Propolis—beta-cyclodextringrainsCanprotectliverinT2DMfrompimelosisandinflammatorycellinfiltrate.,nleresultsindicatethatpropolis—beta—cyclodextringrainsCanimproveinsulinresistance,decreaseFaGandTGinT2DMrats,itC8、analsoimprovetheabilityofantioxidationandCallpreventandcuretheDFL.Keywords:propoli
3、索抵抗Effectsofpropolis·beta-cyclodextringrainsonoxidativestressandDiabeticfattyliver(DFL)intype2diabetesmellitus(T2DM)ratsHUFu.1ian91,LIYa-jin92,CHENMin—li3(1.College巧AnimatSciences,ZjejiangUniversity,aangzhou310029,China;2.CollegeofMedicine,刁l嘶肌gUniversity,magzhOil310030,Chi
4、na;3.Zhe#angTraditionalChineseMedicinalUniversity,Hangzhou310053,China)Abstract:Theeffectsofpropolis—beta-cyciodextringrainsonoxidativestressandDFLwereevaluatedbydeterminingthechangesoffastingbloodglucose(FaG),fastinginsulin(FINS),insulinactindex(IAI),triglycerides(TG),tota
5、lcholesterol(TC),highdensitylipoproteincholesterol(HDL-C),lowdensitylipoproteincholesterol(LDL—C),superoxidedismutase(SOD),Malonaldehyde(MDA),AlanineAminotransferase(ALT),AspartateAminotransferage(AST)andliverpathologicalfeatures.Theresultsshowedthattherewerenosignificantdi
6、fferenceexhibitedinLDL-Clevel,HDL.Clevel,Tc,ALTandASTlevelbetweenpropolis—beta-cyclodextringrainstreatmentgroupsandT2DMmodelcontrolgroup.Treatedwithpropolis—beta-cyclodextringrainscansignificantlydepresstheserumlevelofFBGandTG(P<0.01,P<0.05),decreasethecontentofMDA(P<0.01,P
7、<0.05),andimproveIAIandSOD(P<0.05),comparedwithmodelcontrolgroup.Propolis—beta-cyclodextringrainsCanprotectliverinT2DMfrompimelosisandinflammatorycellinfiltrate.,nleresultsindicatethatpropolis—beta—cyclodextringrainsCanimproveinsulinresistance,decreaseFaGandTGinT2DMrats,itC
8、analsoimprovetheabilityofantioxidationandCallpreventandcuretheDFL.Keywords:propoli
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