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ID:18110378
大小:321.50 KB
页数:7页
时间:2018-09-14
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1、肝癌治疗后AFP增高患者的18F-FDGPET/CT与增强CT对照研究陈陈、梁梁、张张##大学附属第#医院#医学科【摘要】目的:探讨18F-FDGPET/CT在监测肝细胞癌(HCC)治疗后AFP增高患者中肿瘤残余复发及肝外转移的临床价值,并比较18F-FDGPET/CT与增强CT(CECT)在肝内病灶的检出差异。方法:回顾性分析54例HCC治疗后AFP增高患者的18F-FDGPET/CT及CECT表现,两者的间隔时间≤2周。结果经病理或影像学、血清AFP水平监测等临床随访(>6个月)证实。结果:45例肝内残余复发,9例肝内未见残余复发;23例肝外转移,其中19例肝内残余复发并肝外转移,4
2、例仅发现肝外转移。18F-FDGPET/CT及CECT对肝内病灶检出的灵敏度、特异度、准确性分别为88.9%(40/45)、57.8%(26/45),77.8%(7/9)、100%(9/9),87.0%(47/54)、64.8%(35/54),18F-FDGPET/CT灵敏度及准确性优于CECT(X2分别为12.621、8.205,P值均<0.01)。同时18F-FDGPET/CT对肝外转移病灶的灵敏度为100%(23/23)。结论:在HCC治疗后AFP增高患者中,18F-FDGPET/CT不但能早期诊断肝内肿瘤残余复发,并能有效地发现肝外转移;而且18F-FDGPET/CT对肝内病灶检
3、出的灵敏度及准确性明显优于CECT。关键词:18F-FDG;PET/CT;治疗后;肝细胞癌;AFPComparedtheclinicalvalueof18F-FDGPET/CTwithCECTinhepatocellularcarcinomapatientsaftertherapywithserumAFPelevation【Abstract】Objective:Toassesstheclinicalusefulnessof18F-FDGindetectingoftumorresiduaorrecurrenceandmetastasisforpatientswithserumAFPelev
4、ationaftertherapyofhepatocellularcarcinoma(HCC).andComparethedifferencesofPET/CTandcontrastenhancedcomputedtomography(CECT)indetectingofliverlesion.MethodsThefindingof18F-FDGPET/CTandCECTin54HCCpatientswhichhadAFPelevationaftertherapywerestudiedretrospectively.Theresultswereconfirmedbypathologyor
5、imagingfollow-upandthemonitoringofserumAFPlevelbyclinicalfollow-up(>6months).Results:45patientshavebeendiagnosedwithHCCfocalsurvival,recurrenceaftertreatment.ninepatientsdidnotdevelopHCCfocalsurvivalorrecurrence.23patientsdevelopedextrahepaticmetastasis.19patientsdevelopedextrahepaticmetastasisas
6、sociatedwithfocalsurvivalorrecurrence.Fourpatientsonlydevelopedextrahepaticmetastasis.Thesensitivity,specificity,accuracyof18F-FDGPET/CTforliverlesioninthedetectionofHCCrecurrencewere88.9%(40/45)、77.8%(7/9),87.0%(47/54)respectively.InCECT,thecorrespondingvalueswere57.8%(26/45)、100%(9/9)、64.8%(35/
7、54).Therefore,thesensitivityandaccuracyof18F-FDGPET/CTissignificantlyhigherthanthatofCECT.Conclusion:18F-PET/CThasahighsensitivityandaccuracycomparingwithCECTindetectingthelocaltumorresiduaorrecurrenofHCCintheinthelive
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