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时间:2018-09-01
《胃癌组织中增殖诱导配体及受体mRNAs表达的病理意义.doc》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、胃癌组织中增殖诱导配体及受体mRNAs表达的病理意义作者:张健锋毛振彪许钟朱惠君章建国倪润洲【摘要】目的:研究增殖诱导配体(APRIL)及其受体B细胞成熟抗原(BCMA)和穿膜蛋白活化物(TACI)mRNA在胃癌组织中的表达,探讨其临床病理意义。方法:收集30例胃癌及相应癌旁正常胃组织,应用RT-PCR检测APRIL及其受体mRNA在胃癌及癌旁胃组织中的表达。结果:胃癌组织APRILmRNA阳性率(26/30,86.7%)明显高于癌旁胃正常组织(12/30,40.0%)(P<0.01),在肠型胃癌中的表达高于弥漫型(P<0.05),与年龄、性别、病灶大小、临床病理分期、分化程度、浸润深度、淋巴
2、结转移等因素无关。而APRIL受体mRNA在胃癌和癌旁胃组织中表达无差异,且与年龄、性别、病灶大小、临床病理分型和分期、分化程度、浸润深度、淋巴结转移等因素无关。结论:APRILmRNA异常表达与肠型胃癌的发生有关,检测其表达水平有助于胃癌的早期诊断。【关键词】胃癌;增殖诱导配体;B细胞成熟抗原;穿膜蛋白活化物[Abstract]Objective:Toinvestigatetheexpressionandclinicalsignificanceofaproliferation-inducingligand(APRIL)anditsreceptorsBcellmaturationantigen
3、(BCMA),transmembraneactivatorandcalciummodulatorandcyclophilinligandinteractorprotein(TACI)mRNAingastriccancerpatients.Methods:Reversetranscriptase-polymerasechainreaction(RT-PCR)wasusedtoexamineAPRILanditsreceptorsmRNAin30primarygastriccarcinomoustissueandtheadjacentnormaltissue.TheexpressionofAPRI
4、LanditsreceptorsmRNAsinpatientswithvariouspathologicalcharacteristucswereanalyzed.Results:PositiveAPRILexpressionwasobservedin86.7%ofthegastriccancercases,while40%inadjacentnormaltissues.SignificantdifferencesintheexpressionofAPRILmRNAwasfoundinadjacentnormaltissuesandthegastriccancercases(P<0.01
5、),alsoshowedastatisticallysignificantdifferencebetweenintestinal-typeanddiffuse-typegastriccarcinoma(P<0.05),whilenosignificantdifferencesintheexpressionofBCMAandTACI(P>0.05),andnosignificantdifferencesintheexpressionofthetumorsize,differentiatedsubtypes,infiltratedepth,lymphaticmetastasesandT
6、NMclinicalstage(P>0.05).Conclusion:Over-expressionofAPRILmRNAinhumangastrictissuesmayplayanimportantroleinthecarcinogenesisoftheintestinal-typegastriccarcinoma,detectionofAPRILmRNAwillbebeneficialtodiagnosishumangastriccancer.[Keywords]Gtastriccarcinoma;Proliferation-inducingligand;B-cell5maturat
7、ionantigen;Transmembraneactivatorandcalciummodulatorandcyclophilinligandinteractorprotein胃癌是消化道最常见的恶性肿瘤之一,我国恶性肿瘤中胃癌发病率位居第3位[1]。寻找经济、实用、有效的肿瘤分子标志及早识别胃黏膜癌变是目前的研究热点。本研究应用RT-PCR检测胃癌组织中增殖诱导配体(aproliferatio
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