effect of environmental endotoxin exposure on development of pediatric asthma among egypytian school children

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1、EffectofenvironmentalendotoxinexposureondevelopmentofpediatricasthmaamongEgypytianschoolchildren×÷ÕߣºMalakShaheen1,SherinElSayed2,AhmedAbdelKarim3,AlfridEdward1andMagidIbrahim1¡¾ÕªÒª¡¿Objective:Theaimofthisstudywastoassessschoolindoorexposuretomicrobialproductsandprevalenceofasthmaandallergie

2、sinruralandurbanchildren.Methods:Thisstudywascarriedonaruralandanurbanschool.Environmentalendotoxinlevelwasmeasuredinmultiplesamplesoftheambientindoorairdustcollectedonspecialasepticfilterpapersfromthetwoschools.Fortwohundredchildrenhistorytaking,clinicalexamination,allergenskinpricktestandbas

3、icpulmonaryfunctiontestwerepreformed.Results:Environmentalendotoxinlevelsshowedsignificantlyhighermeanvalues(P<0.01)inruralschool(3EU/mg)ascomparedtotheurbanschool(0.1EU/mg)with(OR=5.163;95%CI:0.95ª²28).Historyofallergicsymptomswassignificantlymoreinurbanthanruralstudents(P=0.01).Meanvalues

4、ofpulmonaryfunctionparametersweresignificantlylowervaluesinurbanstudentscomparedtoruralstudents.Skinpricktestresultsshowedsignificant26reactionstoalltestedallergensinurbanchildrencomparedtoruralchildren(P<0.05).Conclusion:Thereisaninverseassociationbetweenenvironmentalexposuretoendotoxinsan

5、dsusceptibilityforallergicmanifestationsinschoolchildren.¡¾¹Ø¼ü´Ê¡¿Endotoxin;Environmental;School;Urban;Ruralandpediatricasthma¡¡¡¡INTRODUCTION¡¡¡¡Therehasbeenasignificantincreaseintheprevalenceofallergicdiseasesoverthepast2to3decades[1].Toexplaintheseobservations,environmentalfactorsassociate

6、dwithmoreindustrializedandurbanlivinghavebeenstudiedintensively.However,thereislittleconsistentevidencetosuggestthatobviousriskfactors,suchasincreasedexposuretoindoorallergens,pollution,orchangesindietandbreastfeeding,couldaccountfortheriseinatopicdiseases[2].¡¡¡¡Interestingly,atopicconditions

7、havebecomemoreprevalentatthesametimethatchildhoodinfectiousdiseaseshavebecomelessprevalentworldwide[3].Thesefindings26suggestedthatinfactinfectionsearlyinlifemightprotectfromdevelopingasthmaandallergies.Thisisthesoª²calledhygienehypothe