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ID:14538635
大小:322.00 KB
页数:20页
时间:2018-07-29
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1、Ⅰ.Fillingbanks.1.Asymmetriesofmembranearemaintainedduringfusion.Theinsideofthevesiclesbecausetheoutsideoftheplasmamembraneandthecytoplasmicside.2.Manyproteinsaretargetedbysignalsequencestotheircorrectdestinations,ensuringthattheywillendupinthecorrectme
2、mbraneorcellcompartment.3.Secificproteinaresynthesizedeitheronfreeoronmembrane-boundpolyribosomes.4.Mitochondrial(mt)genomeencodesproteins,withitsownsystem,butmajorityofmitochondrialproteinsaresynthesizedoutsidemitochondrion.20~60aminoacidsequencesmedi
3、atetargetproteinstothematrix,so-calledtranslocation.5.Importinsandexportinsareinvolvedintransportofmacromoleculesinandoutofthenucleus.6.MosteasesofZellwegersyndraneareduetomutationsingenesencodingproteinsinvolvedinimportofperoxisomalproteins.7.Signalpe
4、ptideemergesfromlargesubunitsofribosome.Itrecognizedbysignalrecognitionparticle,whichblocksfurthertranslationafterabout70aminoacids,so-calledelongationarrest.Thenabovecomplexbounddockingproteinonmembrane.8.Chaperonesareproteinsthatpreventfaultyfoldinga
5、ndunproductiveinteractionsofotherproteins.9.ThefungalmetabolitebrefeldingApreventsGTPfrombindingtoARF,whichinhibitstheentirecoatingprocess.10.Vesiclesnon-clathrin--coatedvesiclelieattheheartofintracellulartransport.1.Peroxisomalproteinsare(A)AResponsib
6、leformetabolismofFA,lipids,cholesterol,purline,aa,H2O2BItsimportingaremediatedonlybyPTSsequencesCOnlycom(酶)isneededduringitsimportingDLackoftheseproteincancausecardiovasculardisease2.Zellwegersyndromeiscausedby(C)ATissuescannotsynthesizescytoplasmicenz
7、ymesBAbnormalmetabolismofhemeCmajorfindingisinvolvedinnerologicimpairmentsDMutationsingenesencodingproteinsinvolvedinexportofperoxisomalproteins3.Aboutchaperones(A)AareproteinsthatpreventfaultyfoldingandunproductiveinteractionsofotherproteinsBpossessAT
8、PaseactivityCBiPisatypeofchaperones,cehichcanbindnormalimmunologicDPPIisatypeofdehydrogenase4.WhichofthestepsarethetargetpointthatBrefeldinAinhibitsthecoatingprocessAAeylationofcoatedvesiclesBTargetingofcoatedvesicleCActivationofAREDInh
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