生化复习题(英文)

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1、Ⅰ.Fillingbanks.1.Asymmetriesofmembranearemaintainedduringfusion.Theinsideofthevesiclesbecausetheoutsideoftheplasmamembraneandthecytoplasmicside.2.Manyproteinsaretargetedbysignalsequencestotheircorrectdestinations,ensuringthattheywillendupinthecorrectmembraneorcellcompartment.3.Seci

2、ficproteinaresynthesizedeitheronfreeoronmembrane-boundpolyribosomes.4.Mitochondrial(mt)genomeencodesproteins,withitsownsystem,butmajorityofmitochondrialproteinsaresynthesizedoutsidemitochondrion.20~60aminoacidsequencesmediatetargetproteinstothematrix,so-calledtranslocation.5.Import

3、insandexportinsareinvolvedintransportofmacromoleculesinandoutofthenucleus.6.MosteasesofZellwegersyndraneareduetomutationsingenesencodingproteinsinvolvedinimportofperoxisomalproteins.7.Signalpeptideemergesfromlargesubunitsofribosome.Itrecognizedbysignalrecognitionparticle,whichblock

4、sfurthertranslationafterabout70aminoacids,so-calledelongationarrest.Thenabovecomplexbounddockingproteinonmembrane.8.Chaperonesareproteinsthatpreventfaultyfoldingandunproductiveinteractionsofotherproteins.9.ThefungalmetabolitebrefeldingApreventsGTPfrombindingtoARF,whichinhibitstheen

5、tirecoatingprocess.10.Vesiclesnon-clathrin--coatedvesiclelieattheheartofintracellulartransport.1.Peroxisomalproteinsare(A)AResponsibleformetabolismofFA,lipids,cholesterol,purline,aa,H2O2BItsimportingaremediatedonlybyPTSsequencesCOnlycom(酶)isneededduringitsimportingDLackoftheseprote

6、incancausecardiovasculardisease2.Zellwegersyndromeiscausedby(C)ATissuescannotsynthesizescytoplasmicenzymesBAbnormalmetabolismofhemeCmajorfindingisinvolvedinnerologicimpairmentsDMutationsingenesencodingproteinsinvolvedinexportofperoxisomalproteins3.Aboutchaperones(A)Aareproteinsthat

7、preventfaultyfoldingandunproductiveinteractionsofotherproteinsBpossessATPaseactivityCBiPisatypeofchaperones,cehichcanbindnormalimmunologicDPPIisatypeofdehydrogenase4.WhichofthestepsarethetargetpointthatBrefeldinAinhibitsthecoatingprocessAAeylationofcoatedvesiclesBTargetingofcoatedv

8、esicleCActivationofAREDInh