生化复习题(英文)

《生化复习题(英文)》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、Ⅰ.Fillingbanks.1.Asymmetriesofmembranearemaintainedduringfusion.Theinsideofthevesiclesbecausetheoutsideoftheplasmamembraneandthecytoplasmicside.2.Manyproteinsaretargetedbysignalsequencestotheircorrectdestinations,ensuringthattheywillendupinthecorrectmembra

2、neorcellcompartment.3.Secificproteinaresynthesizedeitheronfreeoronmembrane-boundpolyribosomes.4.Mitochondrial(mt)genomeencodesproteins,withitsownsystem,butmajorityofmitochondrialproteinsaresynthesizedoutsidemitochondrion.20~60aminoacidsequencesmediatetarge

3、tproteinstothematrix,so-calledtranslocation.5.Importinsandexportinsareinvolvedintransportofmacromoleculesinandoutofthenucleus.6.MosteasesofZellwegersyndraneareduetomutationsingenesencodingproteinsinvolvedinimportofperoxisomalproteins.7.Signalpeptideemerges

4、fromlargesubunitsofribosome.Itrecognizedbysignalrecognitionparticle,whichblocksfurthertranslationafterabout70aminoacids,so-calledelongationarrest.Thenabovecomplexbounddockingproteinonmembrane.8.Chaperonesareproteinsthatpreventfaultyfoldingandunproductivein

5、teractionsofotherproteins.9.ThefungalmetabolitebrefeldingApreventsGTPfrombindingtoARF,whichinhibitstheentirecoatingprocess.10.Vesiclesnon-clathrin--coatedvesiclelieattheheartofintracellulartransport.1.Peroxisomalproteinsare(A)AResponsibleformetabolismofFA,

6、lipids,cholesterol,purline,aa,H2O2BItsimportingaremediatedonlybyPTSsequencesCOnlycom(酶)isneededduringitsimportingDLackoftheseproteincancausecardiovasculardisease2.Zellwegersyndromeiscausedby(C)ATissuescannotsynthesizescytoplasmicenzymesBAbnormalmetabolismo

7、fhemeCmajorfindingisinvolvedinnerologicimpairmentsDMutationsingenesencodingproteinsinvolvedinexportofperoxisomalproteins3.Aboutchaperones(A)AareproteinsthatpreventfaultyfoldingandunproductiveinteractionsofotherproteinsBpossessATPaseactivityCBiPisatypeofcha

8、perones,cehichcanbindnormalimmunologicDPPIisatypeofdehydrogenase4.WhichofthestepsarethetargetpointthatBrefeldinAinhibitsthecoatingprocessAAeylationofcoatedvesiclesBTargetingofcoatedvesicleCActivationofAREDInh