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ID:13751233
大小:322.00 KB
页数:20页
时间:2018-07-24
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1、Ⅰ.Fillingbanks.1.Asymmetriesofmembranearemaintainedduringfusion.Theinsideofthevesiclesbecausetheoutsideoftheplasmamembraneandthecytoplasmicside.2.Manyproteinsaretargetedbysignalsequencestotheircorrectdestinations,ensuringthattheywillendupinthecorrectmembra
2、neorcellcompartment.3.Secificproteinaresynthesizedeitheronfreeoronmembrane-boundpolyribosomes.4.Mitochondrial(mt)genomeencodesproteins,withitsownsystem,butmajorityofmitochondrialproteinsaresynthesizedoutsidemitochondrion.20~60aminoacidsequencesmediatetarge
3、tproteinstothematrix,so-calledtranslocation.5.Importinsandexportinsareinvolvedintransportofmacromoleculesinandoutofthenucleus.6.MosteasesofZellwegersyndraneareduetomutationsingenesencodingproteinsinvolvedinimportofperoxisomalproteins.7.Signalpeptideemerges
4、fromlargesubunitsofribosome.Itrecognizedbysignalrecognitionparticle,whichblocksfurthertranslationafterabout70aminoacids,so-calledelongationarrest.Thenabovecomplexbounddockingproteinonmembrane.8.Chaperonesareproteinsthatpreventfaultyfoldingandunproductivein
5、teractionsofotherproteins.9.ThefungalmetabolitebrefeldingApreventsGTPfrombindingtoARF,whichinhibitstheentirecoatingprocess.10.Vesiclesnon-clathrin--coatedvesiclelieattheheartofintracellulartransport.1.Peroxisomalproteinsare(A)AResponsibleformetabolismofFA,
6、lipids,cholesterol,purline,aa,H2O2BItsimportingaremediatedonlybyPTSsequencesCOnlycom(酶)isneededduringitsimportingDLackoftheseproteincancausecardiovasculardisease2.Zellwegersyndromeiscausedby(C)ATissuescannotsynthesizescytoplasmicenzymesBAbnormalmetabolismo
7、fhemeCmajorfindingisinvolvedinnerologicimpairmentsDMutationsingenesencodingproteinsinvolvedinexportofperoxisomalproteins3.Aboutchaperones(A)AareproteinsthatpreventfaultyfoldingandunproductiveinteractionsofotherproteinsBpossessATPaseactivityCBiPisatypeofcha
8、perones,cehichcanbindnormalimmunologicDPPIisatypeofdehydrogenase4.WhichofthestepsarethetargetpointthatBrefeldinAinhibitsthecoatingprocessAAeylationofcoatedvesiclesBTargetingofcoatedvesicleCActivationofAREDInh
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