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1、TheQualityStandardofQuinocetoneKuixitongQuinocetoneＣ18H14N2O3306.32Quinocetoneiscalled3-methyl-2-cinnamicacyl-quinoxalinee-1,4-dioxideinchemistry.ThecontentofC18H14N2O3isnolessthan98.0%indrying.[Character]Thedrugisyellowcrystallineoramorphouspowder,and
2、hasnoabnormalflavour.ItcouldbeeasilydissolvedinCHCl3,dioxaneanddimethylsulfoxide,andslightlyinmethylalcoholandethylalcoholbutnotinwater.[Meltpoint]Meltpointofthedrugis190-193.0℃(basedonVeterinaryPharmacopoeiaofChina,thefirstsupplement,editon2000,page34
3、),meltingcoincidedwithdisintegration.[Identification](1)After0.2gofthedrugisweighedapproximatelyanddissolvedwith10mldimethylformamidecompletely,2mLofthesolutionistakenouttotubeandthen2dropsof1%KMnO4solutionisadded.Onshaking,thecolourwithKMnO4fadesandfu
4、scescentsedimentemerges.(2)50mgofthedrugisaccuratelyputintoa100mLamber-colouredvolumetricflask.Afterdissolvedwith10mLdioxane,thesolutionisdilutedby40%dioxanetothescale.Onshakingcompletely,1mlofthesolutionismeasuredaccuratelyandputinto50mLamber-coloured
5、volumetricflask.Assayingbasedonspectrophotometricmethod(basedonVeterinaryPharmacopoeiaofChina,thefirstsupplement,editon2000,page17),theresultsindicatethatthesolutionhasmaximumabsorptionvalueat231±1nm,260±1nm,314±1nmwavelength.5(3)Absorptionspectrumofin
6、fraredspectrumshouldbeinaccordwithcomparisonspectrum.[Examination]Chloride0.2gofthedrugisweighedand10mLwaterisadded.Thesolutionisheateduntilboiling,andtheniscooledtoroomtemperature.Aftercrystalisseparatedcompletely,thesolutionisfilteredandaddedwithwate
7、rto50mL.Thesolutionisdividedintotwoparts.Basedondeterminationmethod(basedonVeterinaryPharmacopoeiaofChina,thefirstsupplement,editon2000,page51)andcomparedwithstandardsodiumchloridesolution,chlorideofthedrugisnomorethan0.05%.RelatedsubstanceCHCl3isadded
8、tothedruginordertoprepare10mg/mLsolutionfortest.ThesolutionismeasuredaccuratelyanddilutedwithCHCl3to0.05mg/mLascomparisonsolution.Thetwoabovesolutionsshouldbepreparedbeforeused.Basedonthin-layerchromatography(basedonVeterinaryPharmacopo
