systems biology properties of reconstructed networks - bernhard o. palsson

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1、SYSTEMSBIOLOGYGenomesequencesarenowavailablethatenableustodeterminethebiologi-calcomponentsthatmakeupacelloranorganism.Thenewdisciplineofsys-temsbiologyexamineshowthesecomponentsinteractandformnetworksandhowthenetworksgeneratewholecellfunctionscorrespondingtoobservablephenoty

2、pes.Thistextbook,thefirstdevotedtosystemsbiology,describeshowtomodelnetworks,howtodeterminetheirproperties,andhowtorelatethesetophenotypicfunctions.Theprerequisiteissomeknowledgeoflinearalgebraandbiochemistry.Thoughthelinksbetweenthemathematicalideasandbiologicalprocessesarema

3、declear,thebookreflectstheirreversibletrendofincreasingmathemati-calcontentinbiologyeducation.Thereforetoassistbothteacherandstudent,Palssonprovidesproblemsets,projects,andPowerPointslidesinanassoci-atedwebsiteandkeepsthepresentationinthebookconcretewithillustrativematerialand

4、experimentalresults.BernhardØ.PalssonisProfessorofBioengineeringandAdjunctProfessorofMedicineattheUniveristyofCalifornia,SanDiego.SystemsBiologyPROPERTIESOFRECONSTRUCTEDNETWORKSBernhardØ.PalssonUniversityofCalifornia,SanDiegoCambridge,NewYork,Melbourne

5、,Madrid,CapeTown,Singapore,SãoPauloCambridgeUniversityPressTheEdinburghBuilding,Cambridge,UKPublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYorkwww.cambridge.orgInformationonthistitle:www.cambridge.org/9780521859035Thispublicationisincopyright.Subjectto

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7、----hardback----hardbackCambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyofsforexternalorthird-partyinternetwebsitesreferredtointhispublication,anddoesnotguaranteethatanycontentonsuchwebsitesis,orwillremain,accurateorapprop

8、riate.TOMAHSHIDContentsPrefacepageix1Introduction...................