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1、SYSTEMSBIOLOGYGenomesequencesarenowavailablethatenableustodeterminethebiologi-calcomponentsthatmakeupacelloranorganism.Thenewdisciplineofsys-temsbiologyexamineshowthesecomponentsinteractandformnetworksandhowthenetworksgeneratewholecellfunctionscorrespondingtoobservable
2、phenotypes.Thistextbook,thefirstdevotedtosystemsbiology,describeshowtomodelnetworks,howtodeterminetheirproperties,andhowtorelatethesetophenotypicfunctions.Theprerequisiteissomeknowledgeoflinearalgebraandbiochemistry.Thoughthelinksbetweenthemathematicalideasandbiological
3、processesaremadeclear,thebookreflectstheirreversibletrendofincreasingmathemati-calcontentinbiologyeducation.Thereforetoassistbothteacherandstudent,Palssonprovidesproblemsets,projects,andPowerPointslidesinanassoci-atedwebsiteandkeepsthepresentationinthebookconcretewithil
4、lustrativematerialandexperimentalresults.BernhardØ.PalssonisProfessorofBioengineeringandAdjunctProfessorofMedicineattheUniveristyofCalifornia,SanDiego.SystemsBiologyPROPERTIESOFRECONSTRUCTEDNETWORKSBernhardØ.PalssonUniversityofCalifornia,SanDiego
5、Cambridge,NewYork,Melbourne,Madrid,CapeTown,Singapore,SãoPauloCambridgeUniversityPressTheEdinburghBuilding,Cambridge,UKPublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYorkwww.cambridge.orgInformationonthistitle:www.cambridge.org/9780521859035Thi
6、spublicationisincopyright.Subjecttostatutoryexceptionandtotheprovisionofrelevantcollectivelicensingagreements,noreproductionofanypartmaytakeplacewithoutthewrittenpermissionofCambridgeUniversityPress.Firstpublishedinprintformat-----eBook(NetLibrary)
7、----eBook(NetLibrary)-----hardback----hardbackCambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyofsforexternalorthird-partyinternetwebsitesreferredtointhispublication,anddoesnotguaranteethatanycont
8、entonsuchwebsitesis,orwillremain,accurateorappropriate.TOMAHSHIDContentsPrefacepageix1Introduction...................