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1、21世纪器官移植热点，进展及其 发展的新趋势KidneyKidney-PancreasPancreasLiverHeartLungStemCell58816210323523612024928,6951,2015138,9353,1301,5188,775535,07512,9164,086100,17961,19513,710117,984OrganCenters2001TotalWorldwideTransplantDirectoryClinicalTransplants2001KIDNEYRelatedd
2、onorCadaverdonorUnrelatedlivingdonorLIVERHEARTPANCREAS-KIDNEYPANCREASLUNGBONEMARROW393630322320181429UnivColorado-DenverUnivMinnesota-MnplsFMUSP-SaoPauloUColorado-DenverStanfordUnivUnivHosp-ZurichUnivMinnesotaTheTorontoHospFHCRC-SeattleSurvyrsHospitalClinica
3、lTransplants2001LongestSurvivingTransplants-20010246810128789919395979901TransplantYearTransplants(x100)Cecka,ClinicalTransplants2001(p.3)AnnualChangesinLivingDonorRelationships (1988-2000)HLAmmSibParentOffspringHLA-IdSpouseOtherBennett,ClinicalTransplants20
4、01(p.29)AnnualOne-YearPatientSurvivalafterThoracicOrganTransplantation02040608010068-798285941-6 2000YearofTransplant1-YearSurvival(%)HeartHeart-LungLung919788Harper,ClinicalTransplants2001(p.83)DeathsontheUNOSWaitingList0510152025PercentofWaitingPatients889
5、49092969800YearHeartLiverKidneyRosendale,ClinicalTransplants2001(p.87)WaitingListandRecoveredOrgansintheUS020406080889092949698YearWaitinglistCadavericdonororgans00Number(x1,000)Rosendale,ClinicalTransplants2001(p.94)AnnualNumbersofLivingandCadaverDonors0123
6、45688909294969800YearNumberofDonors(x1000)CadaverLivingTransplantYear01020304050PercentOverAge508789919395979901DonorRecipient2030405060MeanAge(Years)8789919395979901DonorRecipientCecka,ClinicalTransplants2001(p.9)AnnualChangesinCadaverDonorandRecipientAgesY
7、ear2030405060MeanAge(Years)8789919395979901DonorRecipient01020304050PercentOverAge508789919395979901RecipientDonorCecka,ClinicalTransplants2001(p.10)AnnualChangesinLivingDonorandRecipientAges器官移植令人瞩目的成绩归于外科技术的日臻成熟更为有效，安全的新型免疫抑制剂的不断推出及临床应用起了重要作用。21世纪随着相关技术的不断
8、突破，将有1/3的疾病的治疗与器官移植有关。21世纪器官移植现状及其 发展的新趋势21世纪初，第18届国际器官移植大会(罗马)，充分肯定了20世纪下半叶在器官移植领域取得的显著成就，并被认为是“人类科学领域发展的巨大一步”。美国UNOS资料:截止2001年止，全球肾脏移植总数535075例，存活率：亲属肾移植最长39年，尸体肾移植最长36年，活体非亲属供肾移植最长30年。肝脏移植100
