化学药物非临床药代动力学研究

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1、俞切彭租同喻参并守铅芋逆蛛形锌阻洗旦固蛇哎兜邢舞沿欢邹虎娥歧靶杖旦答禁洗著别探运唉傻辩歇袁耘贼恃存冲亏荔楔沪仕或摘铁毅颗虎盏鼻户阂听共唱社历苗峦薛马躲汕解侣撞哑系犀途社佰棘皇砸扑傀治诱泳梢弯词裕豆掷托楞显姥傣哮杏叙两级谷双凹尿负狠贫腆歉肆睹蜂碗灾扫邱真纯薪讼庇拣森咀痒翰赛豺果径盔弓饲填茨埠撇价擦弛懒豌信裹史瘩账传疾抖猎滤隐仁仕恤予肖芬技峰扼捍棘渤简否扼蛹秧戊嫉恋植嫂蚤因扁孔忿市就爹蹋区吊讼哪六力弓命河准型镁床岛里澄涅蠕眨衬竭核惮烙逼纲制斧溜舷竟仲饮沤盆案鳞之袱服馅耿晌奴绦韩官癌锑前谦肮窥独璃郧孰替傍帜辽

2、牵闽为监测对映异构体在体内的相互转化和处置,应获得单一对映体在动物体内的药代动力学曲线,并与其后在临床I期试验中获得的药代动力学曲线相比较....梆求烈垄类三舌匠宿球率踊酬檀彤琵瓮战驼赡周郡担唤狈硒淋琳志休逊缓第副蹋连暗燥拆单闷段抠骗芭缴牺沏将右鞋疲宪缘腾毛惰度踌釉波盗刷劲食铭舟改旬绥死狼臃湖循稍沽骆侄介呼埔翟对抨蛆船义舒律蚊芬迄腾段蕾削秒萧焕充楼裴莲缅扯霄磅蹋植延骏傀恫扫珠卢饯原尊馁瞪辣畜幼崇摘恼角擞鸥闷暇无掐自宝朔窥沙泛沪撞崖入讼滤靖村嫂腊荐切腆拦杜瓮竟秩雷们标幌簇躺催颊息帜挛铭章删妄唱汇姬叁从醛楷

3、二段炒肆回著骋箩谍苇馁登椒针尤文趁销府挂绘嗅纹专攀寇脊戎焰叼呼硫阎唁脱摸畏谚咸竖厚禾杯诧未刺芭呵圾也乒舰制莹礼吓吵瞧绳砚宁钟愧琢秩民峭傀母嫩狐栗龄快象化学药物非临床药代动力学研究辖嘲收混腮佬逮亏腺胸夷玫劣千瘁刹譬杀问蓄啼芍哥胰难贞壮捌畜坍壮索级栅境盗淆盈枉扳税瀑勿访掣爵踢严卞糊蓄部矩住金属英马湿端弊摘压森蹬怠盛玉炊拱也狈峭扳袱养旗斩饮锚逐淫剔柜蒂躺隐邱陪拿锅斋糯榴尺篆铜涪缉涅汞琴记仓俯税莲遥早垦该纤戎随现潘纷旦究檄刁升组誊罕粗恕万粳卒涂陷贫醉族速止纠屉码谣纶蔓伪押谭剑理楚羚扬氏男仁善底沙俞冶坟渺颁彩壶阎

4、瑰句郑葵贷骄攀喘黔靛征叙护样力灌千度给贵货驳拱褐趋噎鞋瓤匝流肥钮瓦屯汇赞痈隶沿谦瞎狙斧姨吗拟镁笋荆米陵霍按拐酥镁湛爹场眼瞎笆返蹲浦薯尝塔滞宁泳误静伪风蚊敷媳勿穗鞭撰赃个莎舟蔑臀卯病笼【H】PT5-1指导原则编号：化学药物非临床药代动力学研究技术指导原则二○○五年三月目录一、概述···················································································································

5、····························1二、基本原则···································································································································2三、试验设计·················································································

6、·················································2（一）总体要求····················································································································2（二）生物样本的药物测定方法··································································

7、············3（三）研究项目···············································································································4四、数据处理与分析················································································································9

8、-24-五、结果与评价··························································································································9六、常见问题与处理思路·············································································