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1、辛伐他汀联合氯沙坦对兔动脉粥样硬化相关因子的影响(1天津医科大学第二医院心脏科天津心脏病学研究所天津3002112天津市滨海新IX大港医院急诊科天津3002703天津市胸科医院心脏科天津300350目的研究氯沙坦、辛伐他汀单独以及联合应用对兔动脉粥样硬化的影响和机制。方法46只新丙兰雄性大白兔适应性喂养1周后随机分为空白对照组、高脂组、氯沙坦组、辛伐他汀组、氯沙坦+辛伐他汀组，观察各组药物干预前后体重、血脂、炎症因子的变化。结果动脉粥样硬化模型建立后，高脂组及药物干预组血脂水平显著高于空白对照组(P<0.05)，高脂组与药物干预组间
2、比较无统计学差异。药物干预8周后，药物干预组IL-6、MCP-1均明显低于高脂组(P<0.05),氯沙坦+辛伐他汀组IL-6较氯沙坦组、辛伐他汀组无差异(P>0.05),MCP-1较氯沙坦组有明显下P<0.05),氯沙坦与辛伐他汀组组间无差异(P>0.05)o氯沙坦组、辛伐他汀组PPARγ无明显差异(P>0.05),氯沙坦+辛伐他汀组PPARγ较其他组别明显升高(P<0.05)o药物干预组比高脂组内膜中膜厚度比均有显著下降(P<0.05),氯沙坦+辛伐他汀组较氯沙坦组、辛伐
3、他汀组明显降低P<0.05)o结论氯沙坦及辛伐他汀均能显著减少内膜中膜厚度比，稳定血管斑块，联合治疗具有更强的延缓动脉粥硬化进程的作用，独立于降低血脂的抗动脉粥样硬化作用可能与降低炎症因子密切相关。关键词：氯沙坦辛伐他汀白介素-6单核细胞趋化蛋白-1过氧化物酶体增殖物激活受体γ【】R543.5【】A【】1001-5213(2016)09-0122-02R543.5BSynergeticeffectoflosartanandsimvastatinonatherosclerosisrelatedfactorsinrabbit
4、sZHANGZong-yanl.2,XUYan-Minl,LIUYuan-ying3(1.DepartmentofCardiology,TianjinInstituteofCardiology,theSecondHospitalofMedicalUniversity,Tianjin300211；2.Emergencydepartment,DagangHospitalofTianjinBinhaiNewArea,Tianjin300270,China；3DepartmentofCardiology,TianjinThoracicHospit
5、al,Tianjin300350,China)ABSTRACT:ObjectiveToinvestigatetheeffectandmechanismofsimvastatinandlosartansynergisticallyinhibitetheatherosclerosisprogressioninrabbits.Methods46NewZealandmalerabbitsadaptivefeededafter1weekwererandomlydividedintofivegroups:normalcontrolgroup(NCgr
6、oup),high-cholesterolgroup(ASgroup),Losartangroup(Lgroup),Simvastatingroup(Sgroup)andLosartanSimvastatingroup(LSgroup).Thelevelofweights,lipidsandinflammatoryfactorsweredetectedbeforeandeightweeksafterthedrugsintervention.ResultsAfterwebuiltedtheASmodel,thelipidlevelofASg
7、roupanddruginterventiongroupwerehighercomparedwithNCgroup.Therewasnosignificantdifference(P>0.05)betweenASgroupanddruginterventiongroup.After8weeksdrugsintervention,theIL-6andMCP-1levelindrugsinterventiongroupweresignificantlylower(P<0.05)thanASgroup.Therewasnosigni
8、ficantdifferencebetweenIL-6levelat12thweekinLSgroupandSgroupatsamepointoftime(P>0.05).MCP-1le
