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1、Wishart14MS#200201391BrainActivationPatternsAssociatedwithWorkingMemoryinRelapsing-RemittingMSHeatherA.Wishart,Ph.D.a,AndrewJ.Saykin,Psy.D.ac,BrennaC.McDonald,Psy.D.a,AlexanderC.Mamourian,M.D.c,LauraA.Flashman,Ph.D.a,KimberlyR.Schuschu,B.A.a,KathleenA.Ryan,R.N.
2、b,CamiloE.Fadul,M.D.b,&LloydH.Kasper,M.D.bDepartmentsofPsychiatrya,Medicine(Neurology)b,andRadiologycDartmouthMedicalSchool/Dartmouth-HitchcockMedicalCenterLebanon,NewHampshire03756-0001AbstractWordCount:165ArticleWordCount:2265Additionalmaterialrelatedtothisar
3、ticlecanbefoundontheNeurologyWebsite.Gotowww.neurology.organdscrolldowntheTableofContentsforthe___issuetofindthelinkforthisarticle.TheauthorsaregratefulforthehelpofRobertFerrantiandcolleaguesintheMRICenter,StephenGuerin,B.S.,RobertM.Roth,Ph.D.,JenniferStoneRami
4、rez,M.Sc.,FilliaMakedon,Ph.D.,JamesC.Ford,Ph.D.,BenNordstrom,M.D.,JenniferSchoenfeld,Ph.D.,LeslieBaxter,Ph.D.,andJohnMacDonald,M.A.SupportedinpartbygrantsfromtheNationalMultipleSclerosisSociety,theHitchcockFoundation,theNationalInstituteofNeurologicalDisordersa
5、ndStroke,theNationalInstituteofAllergyandInfectiousDiseases,NationalScienceFoundation,andtheIraDeCampFoundation.Wishart14AbstractBackground:Patientswithmultiplesclerosis(MS)showchangesinbrainactivationpatternsduringvisualandmotortasksthatincludedecreasesinthety
6、picallocalnetworkforafunction,andincreasesinotherbrainregions.Objective:TodeterminewhetherbrainactivationpatternsassociatedwithworkingmemoryareaffectedbyMS.Methods:Activationofworkingmemorycircuitrywasexaminedusingafunctionalmagneticresonanceimaging(fMRI)n-back
7、taskinadultswithmildrelapsing-remittingMS(RRMS;n=10)anddemographically-matchedhealthycontrols(n=10).Results:Groupdifferencesinbrainactivationemergedduringbothlow-andhigh-demandconditions(p<.001).Overall,patientsshowedlessactivationthancontrolsincoreprefrontalan
8、dparietalregionsofworkingmemorycircuitry,andgreateractivationinotherregionswithinandbeyondtypicalworkingmemorycircuitry,includingbilateralmedialfrontal,cingulate,parietal,bi
