乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效观察

《乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效观察》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效观察新疆医科大学第二附属医院呼吸科乌鲁木齐830063目的：观察乙酰半胱氨酸泡腾片联合布地奈德治疗特发性肺纤维化的临床疗效。方法：选取我院呼吸科2012年1月一2015年6月住院治疗的IPF患者30例，随机分为两组，观察组给予布地奈德混悬液lmg/次，2次/d，每次15min,氧驱动雾化吸入。同时给予乙酰半胱氨酸泡腾片600mg/次，3次/d，温开水溶解后服用。对照组给予泼尼松0.5mg/(kg•d)分次口服，连用4周后减量至0.2

2、5mg/(kg•d)o8周后对比两组临床疗效。结果:观察组呼吸困难程度、肺功能、血气水平改善程度均较治疗组有所提高，具有统计学意义(P<0.05),治疗过程屮，观察组不良反应明显少于对照组。结论：乙酰半胱氨酸泡腾片联合布地奈德治疗能显著改善患者临床症状及肺功能，减少并发症的发生,提高患者生存质量，值得临床推广。【关键词】乙酰半胱氨酸泡腾片；布地奈德；特发性肺纤维化ClinicalEfficacyofAcetylcysteineEffervescentTabletsCombineWithBu

3、desonideintheTreatmentofIdiopathicPulmonaryFibrosisMuqingshuang,Hanlimei，Gulixian，DepartmentofRespiration,TheSecondAffiliatedHospitalofXinjiangMedicalUniversity.Urumq,830063,China.[Abstract]Objectivetoobservetheclinicalefficacyofacetylcysteineeffervesc

4、enttabletscombinewithbudesonideinthetreatmentofpulmonaryfibrosisbudesonide.Methods30casesofpatientswithidiopathicpulmonaryfibrosisinourhospitalfromJanuary2012toJune2015wererandomlydividedintotwogroups：observationgroupandcontrolgroup.Observationgroupwas

5、givenbudesonidesuspensionliquid1mg/time，2times/d，each15min，oxygenatomizationinhalation.Whilegivingacetylcysteineeffervescenttablets,600mg/time,3times/d,warmboiledwaterdissolves.Controlgroupwasgivenprednisone0.5/(kg.d)，byseveraltimesoforal，4weeksafterre

6、ductionto0.25mg/(kg.d).After8weekscomparedtwogroupsofclinicalcurativeeffect.ResultsAftertreatment,thedyspneascore，pulmonaryfunction,bloodgaslevelsofobservationgroupweresignificantlyimprovedthanthecontrolgroup.Thedifferencewasstatisticallysignificant(P&

7、lt;0.05).lntheprocessoftreatment，theadversereactionsofobservationgroupwereobviouslylessthanthecontrolgroup.Conclusionacetylcysteineeffervescenttabletscombinewithbudesonidetherapycouldsignificantlyimprovepatient'sclinicalsymptoms，lungfunctionandthequali

8、tyofsurvival,andreducecomplications.Themethodisworthyofclinicalpromotion.【Keywords】Acetylcysteineeffervescenttablets，Budesonide,IdiopathicpulmonaryfibrosisR772A2096-0867(2016)-07-372-02特发性肺纤维化(IPF)是一种病因不清，以间质性肺炎为病理改变的慢性纤维性炎性肺疾病，临床表现为进行性