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1、亚临床甲状腺功能减退对2型糖尿病患者临床及生化指标的影响[]目的探讨亚临床屮状腺功能减退(subclinicalhypothyroidism,SCH)对2型糖尿病(type2diabetesmellitus,T2DM)患者临床及生化指标的影响。方法161例T2DM患者根据促甲状腺激素(TS11)值分为SC11组78例和对照组83例,比较两组的年龄、性别、血压(收缩压SBP、舒张压DBP)、体重指数(BMI)、糖化血红蛋白(HbAlc)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低
2、密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hey)水平的差异。结果两组间TC、LDL-C、UA、hs-CRP、Hey、TSH有统计学差异(P〈0.05),两组间年龄、性别、BMI、SBP、DBP、HbAlc、TG、HDL-C、FT3、FT4无统计学差异(P〉0.05)。相关分析显示,TSH与TC、LDL-C、UA、hs-CRP、Hey呈正相关(P〈0.05)。二元Logistic回妇分析显示LDL-C、UA、hs-CRP、Hey是SCH发生的独立危险因素(P
3、〈0.05)。结论合并SCH的T2DM患者更易发生血脂、UA、hs-CRP、llcy等代谢及炎症指标异常。,供学习和研究使用,版权和著作权归原作者所右,如存不愿意被转载的情况,己如果需要分享,请保留本段说明。[关键词]亚临床甲状腺功能减退;血脂;尿酸;超敏c反应蛋白;同型半胱氨酸[]R581.2;R587.1[]A[]1673-9701(2017)14-0012-03[Abstract]ObjectiveToexploretheeffectofsubclinicalhypothyroidism(SCH)on
4、theclinicalandbiochemicalindexesoftype2diabetesmcllitus(T2DM)patients.Methods161patientswithT2DMweredividedintoSCIIgroup(n=78)andcontrolgroup(n=83)accordingtothevalueofthyroidstimulatinghormone(TSH).Thedifferencesinage,sex,bloodpressure(SBP,DBP),bodymassin
5、dex(BMI),glycatedhemoglobin(HbAlc),totalcholesterol(TC),triglyceride(TG),highdensitylipoproteincholesterol(I1DL-C),lowdensitylipoproteincholesterol(LDL-C),uricacid(UA),highsensitivityCresponseprotein(hs-CRP)andhomocysteine(Hey)levelsbetweenthetwogroupswere
6、compared.ResultsThereweresignificantdifferencesinTC,LDL-C,L'A,hs-CRP,HeyandTSIIbetweenthetwogroups(P〈0.05).Therewerenosignificantdifferencesinage,sex,BMI,SBP,DBP,HbAlc,TG,HDI-C,FT3,FT4betweenthetwogroups(P>0.05).CorrelationanalysisshowedthatTSHwaspositivel
7、ycorrelatedwithTC,LDL-C,UA,hs-CRPandHey(P<0.05).BinaryLogisticregressionanalysisshowedthatLDL-C,UA,hs-CRPandHeywereindependentriskfactorsofSCH(P<0.05)•ConclusionPatientswithT2DMcombinedwithSCIIweremorepronetohaveabnormalitiesinmetabolicandinflammatoryindic
8、atorsincludingbloodlipids,UA,hs-CRPandHey.[Keywords]Subclinicalhypothyroidism;Bloodlipids;Uricacid;HypersensitiveC-reactiveprotein;Homocysteine糖尿病和甲?钕偌膊【?是常见的内分泌代谢疾病。研究发现2型糖尿病(type2diabetesmellitus,T2DM)患者甲状腺