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1、帕利哌酮缓释片用于儿童期首发精神分裂症治疗临床研究陆志新张霞石磊李志佳(无锡市精神卫生中心江苏无锡214151)目的：探讨将帕利哌酮缓释片用于治疗儿童期首发精祌分裂症患的疗效及优缺点。方法：回顾性分析40例应用帕利哌酮缓释片治疗的儿童期首发精神分裂症患者临床资料，以其用药前后的病情进行自身对比，用药6个月后观察其疗效和不良反应。结果：至用药结朿时为止，患者治疗的总有效率为87.50%,PANSS评分、阳性症状分量表、一般精神病理分量表评分相比于治疗前有了明显的改善(P<0.05),于用药1周末、2周末、3月末、6月末时，均较治疗前的症状有了显著的缓解(P<0.01)
2、,阴性症状分量表评分于用药1周后开始下降，至用药结束时，较治疗前有了明显的下降(P<0.01)。不良反应轻微多可自行缓解。结论：帕利哌酮缓释片用于儿童期首发精神分裂症患者治疗,起效较快，药效明显，不良反应轻微，服药依从性较好，值得推广使用。【关键词】帕利哌酮缓释片；儿童精神病；首发精神分裂：疗效R453A2095-1752(2015)09-0049-02ClinicalstudyofchildhoodschizophreniatreatmentPaliperidoneExtended-ReleaseTabletsfor.LuZhixin,ZhangXia,ShiLe,iL
3、iZhijia.MentalHealthCenterofWuxiCity,JiangsuProvince,Wuxi214151,China【Abstract】Objective:Toinvestigatethepaliperidoneextendedreleasetabletsforthetreatmentofchildhoodschizophreniaepisodeefficacyandadvantagesanddisadvantagesofsuffering.Methods:Aretrospectiveanalysisof40casesofchildhoodApplicat
4、ionpaliperidoneextendedreleasetabletsinthetreatmentoffirstclinicaldataofpatientswithschizophrenia,withitsownconditionsbeforeandaftertreatmentwerecomparedtoevaluateefficacyandadversereactions6monthsaftertreatment.Results:Attheendoftreatmenttodate,patientstreatedwithtotaleffectiverate87.50%,PA
5、NSSscore,positivesymptomssubscale,generalpsychopathologysubscalescorehasbeensignificantlyimprovedcomparedtobeforetreatment(P<0.05),inmedicine1week,2weeks,theendofMarch,whentheendofJune,comparedwithpre-treatmentofthesymptomshavebeensignificantlyalleviated(P<0.01),negativesymptomssubscal
6、escoresat1weekaftertreatmentbegantodecline,untiltheendoftreatment,comparedwithtreatmentformerhaddroppedsignificantly(P<0.01).Adversereactionsweremildandmorecanrelieveitself.Conclusion:paliperidoneextendedreleasetabletsforthetreatmentofpatientswithschizophreniainchildhoodepisode,rapidonset
7、,efficacysignificantly,adversereactionsaremild,bettermedicationcompliance,shouldbeintroduced.【Keywords】Paliperidoneextendedreleasetablets;Childpsychiatry;Episode精神分裂症属精神障碍性中枢神经系统疾病的一种，患者病情迁延，社会能力明显下降，儿童精神分裂症是指起病于18岁以前的青少年儿童的一种精神疾病^】，其发病率不高，但与成人型精神分
