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1、COVERLETTERDate:20-5-2014Place:BangaloreFrom,PreethiV.GDepartmentofBiotechnology,TheOxfordcollegeofEngineering,Bommanahalli,Hosurroad,Bangalore–560068,Karnatakastate,IndiaPhoneNo:9880831891Fax:080-30219629To,TheEditor-in-Chief,WorldJournalofPharmaceuticalSciences,Web:http://www.wjpsonl
2、ine.org/Sub:SubmissionofManuscriptArticleType:ResearchArticleRespectedSir,Withreferencetotheabove,pleasefindmysubmissionofpaperentitledwithIDENTIFICATIONOFOVEREXPRESSEDGENESINESOPHAGEALSQUAMOUSCELLCARCINOMAUSINGRNA-SeqMETHODforpossiblepublicationsinyouresteemedjournal.Iherebyaffirmthat
3、thecontentofthismanuscriptisoriginal.Furthermoreithasbeenneitherpublishedelsewherefullyorpartiallyoranylanguagenorsubmittedforpublication(fullyorpartially)elsewheresimultaneously.Ialsoaffirmthatalltheauthorshaveseenandagreedtothesubmissionofpaperandtheirinclusionofname(s)asco-author(s)
4、.Iamlookingforwardtohearfromyou.ThankingyouSincerelyyours,Preethi.V.G1IDENTIFICATIONOFOVEREXPRESSEDGENESINESOPHAGEALSQUAMOUSCELLCARCINOMAUSINGRNA-SeqMETHOD1PreethiV.G,1*IndiraPriyadarsiniR,and1KusumPaul.1DepartmentofBiotechnology,TheOxfordcollegeofEngineering,Bommanahalli,Hosurroad,Ban
5、galore–560068,Karnatakastate,India.*Correspondingauthoremailindira8791@gmail.comTelephone+919742088554ABSTRACT:EsophagealSquamousCellCarcinoma(ESCC)isatypeofcancerandmaybecausedduetothevariationatthetranscriptlevel.Aberrantvariationsinsplicingmayleadtotheprogressionofcancer.Identificat
6、ionofsuchspliceformscanbeusedasagoodbiomolecularmarker.WiththeadventofRNA-Seqmethodtherehasbeenatremendousapplicationsindiscoveryfrontandimprovementinhealthcare.TheapplicationsofRNA-Seqmethodarevast,includinggenomeassemblytogenomecorrectionanditsannotationinnumerousorganisms.RNA-Seqmet
7、hodanalysishavediscoverednovelbiomarkersfortheearlydiagnosisofvariousdiseases.Howevertheexpressionofgenesattranscriptlevelsandidentificationofnovelspliceformshasnotbeendoneatalargerscale,whichcouldbeusedtoidentifypotentialbiomarkersforESCC.HereESCCsampledatasets(onetumordatasetandone
