代谢组学进展ppt课件

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1、TheNeedforBiomarkersinDiagnosisandPrognosisofDrug-InducedLiverDisease:DoesMetabolomicsHaveAnyRole?生物标志物在药物诱导的肝脏疾病的诊断和预断中的需要：代谢组学是否有何作用？1.IntroductionLiverinjuryduetobothprescriptionandover-the-counterdrugsisagrowingpublichealthproblem.Althoughdrug-inducedliverinjury(DILI)isararecauseofacuteli

2、verinjuryinclinicalpractice,itistheleadingcauseofacuteliverfailure(ALF)intheUSandmostofEurope.处方药和非处方药导致的肝损伤是一个日益严重的公共卫生问题。尽管药物诱导的肝损伤（DILI）在临床实践中是急性肝损伤的罕见原因，但它是美国和大多数欧洲的急性肝衰竭（ALF）的主要原因1.IntroductionDespitetheextensivesafetytestsperformedintheprocessofgettingadrugtomarket,DILIremainsenigmatica

3、ndcannotbepredictedinpreclinicalandclinicaltrials.EventhoughdifferentgeneticvariantsandbiomarkershavebeenassociatedwiththeriskofdevelopingDILI,hepatotoxicityremainsaverycommonsideeffect.尽管在药物上市的过程中进行了广泛的安全性测试，但肝损伤仍然是神秘的，并且不能在临床前和临床试验中预测。不同的遗传变异体和生物标志物与肝损伤发展的风险相关，肝毒性仍然是非常常见的副作用。1.IntroductionI

4、nthisreviewwewillfocusonthepotentialroleofmetabolomicstudyonthediagnosisandprognosisofDILI.在这篇综述中，我们将重点关注代谢组学在肝损伤的诊断和预断中的潜在作用。2.TheMainChallengesinDILI:AccuracyofDiagnosisandPredictionofEvolutionCurrently,DILIisdiagnosedbyexclusionofotherliverdiseasesandisfrequentlymisdiagnosed.Animportantpar

5、tinthediagnosisofDILIistoestablishatemporalassociationbetweenadrugandtheonsetofliverdamage.However,inmanycases,settingacausallinkcanbeacomplextaskasmostoftheidiosyncraticdrug-inducedreactionsoccurroughlybetweenarangeof1-2weeksand2-3monthsfromtheonsetofdrugadministration目前，肝损伤是通过排除其他肝病进行诊断的，而且

6、经常被误诊。DILI诊断的一个重要部分是建立药物与肝损伤起始之间的时间关联。然而，在许多情况下，设置因果关联可以说是一件复杂的任务，因为大多数特异性药物诱导的反应大致在给药开始的1-2周和2-3个月的范围内才发生2.TheMainChallengesinDILI:AccuracyofDiagnosisandPredictionofEvolutionImportantly,ourknowledgeisscarcenotonlyintermsofdiagnosticaccuracy.ThenaturalhistoryofDILIisstillnotcompletelyundersto

7、od重要的是，我们的知识不仅在准确诊断性方面知道的很少。而且肝损伤的自然史仍然没有完全理解2.TheMainChallengesinDILI:AccuracyofDiagnosisandPredictionofEvolutionmetabolomicsisemergingforcefullyinordertoidentifyearlytoxicitybiomarkersfrombiofluidscollectedthroughminimallyinvasiveprocedures