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1、105.J.L.RombeauandD.O.Jacobs,"NasoentericTubeFeed-latterratemaybemisleadingifthemodificationoccursing,"inJ.L.RombeauandM.D.Caldwell,eds.,Enteralandduringextendedincubationintheprocess.TubeFeeding,W.B.Saunders,Philadelphia,Penn.1984.pp.XX-XX.106.A.H.McArd
2、leetal.,"ARationaleforEnteralFeedingasthepH,Temperature.ThepHandtemperatureoptimumPreferableRouteforHyperalimentation,"Surgery90,613-curvespublishedbysuppliersusuallyconfoundthetrue623(1981).influenceofthesefactorsonenzymecatalyticproperties107.T.Jones,"
3、EnteralFeeding:TechniquesofAdministration,"withtheeffectonenzymestability.EnzymedenaturationGut27,47-49(1986).isinfluencedbynumerousfactors,isusuallyirreversible,108.C.Page,R.Andrassay,andJ.Sandier,"TechniquesinDeliv-andoccurswithfirst-orderkinetics.Opti
4、mumcurvesareeryofLiquidDiet:Short-TermandLong-Term,"inM.Deitel,constructedusingassaysthatmeasuretheamountofsub-ed.,NutritioninClinicalSurgery,Williams&Wilkins,Bal-stratemodificationoveraperiodoftimeandrepresentatimore,Md.,1985,pp.60-87.summationoftruerat
5、eeffectsplusdenaturationduring109.J.Rombeauetal.,"FeedingbyTubeEnterostomy,"inJ.L.thattime.Theyshouldbeusedwithcaution.RombeauandM.D.Caldwell,eds.,EnteralandTubeFeed-ing,W.B.Saunders,Philadelphia,Penn.,1984,pp.xx-xx.110.L.Y.YoungandM.A.Joda-Kimble,eds.,A
6、ppliedTherapeu-Stability.Thepresenceofsubstratestabilizesenzymetics:TheClinicalUseofDrugs,4thed.,AppliedTherapeu-againstdenaturation;thus,therealoptimumofinterestistics,Vancouver,Wash.,1988.thestabilityofenzymeundertheconditionsofuse:time,111.Regulations
7、forFoodLabeling:ConventionalFoods,21CFRpH,temperature,substrateconcentration,inorganicions,PART101,FoodsforSpecialDietaryUse,21CFRPart105.organicsolvents,andsoon.Anassayusedtoscreenen-112.DefinitionofMedicalFood,OrphanDrugAmendmentsofzymesforaparticulara
8、pplicationshouldmimicasnearly1988,21USC360e(b)(3).aspossibletheactualuseconditions,togiveareliablees-113.InfantFormulaActof1980,PublicLaw96-359.timateofcostbenefit.DEBRAROONEYSideactivities.Preparingapureisolatedenzymeisco
