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1、JournalofHumanHypertension(2012),1–6&2012MacmillanPublishersLimitedAllrightsreserved0950-9240/12www.nature.com/jhhREVIEWProteomicsinhypertension121DMCarty,ESchifferandCDellesProteomics,thestudyoftheproteinsmakinguptheproteome,hasemergedinrecentyearsasanimporta
2、nttoolinseveraldifferentfieldsofmedicalresearchforearlydiseasedetection,forassessmentofresponsetotreatmentandforunravellingunderlyingpathophysiologicalmechanisms.Althoughthemajorityofpatientswithhypertensionaretreatedinasimilarmanner,thecausesunderlyingthecondi
3、tionarediverse,andoftenpoorlyunderstood.Geneticstudieshaveimplicatedseveraldifferentcandidategenes,butitmaybethatexaminationofthe‘downstream’productsofgenes,theproteins,willhelptoimproveunderstandingofthelinkbetweentheenvironmentalandgeneticeffectsthatcontribu
4、tetowardsdevelopmentofhypertension.Proteomicstudiescanbeperformedquicklyandreliablyonseveraldifferentsampletypesincludingplasmaandurine,requiringminimalpre-testpreparation.Inthisreview,wewillcomparethedifferentanalyticalplatformsandtechnicalissuesinvolvedinpro
5、teomicanalysis.Wewilldiscussexistingstudiesofproteomicsinhypertension,aswellasrelatedconditionssuchasrenaldisease,pre-eclampsiaandcoronaryarterydisease.Wewillalsoexplorepotentialfutureapplicationsofproteomics-basedresearch,whichmayultimatelyleadtoimprovedpopul
6、ationscreening,monitoringoftherapyandearlydetectionoftargetorgandamage.JournalofHumanHypertensionadvanceonlinepublication,9August2012;doi:10.1038/jhh.2012.30Keywords:proteomics;pre-eclampsia;organdamage;cardiovascularriskINTRODUCTIONexactdiseaseprocessesatthet
7、imeofstudy.AsthetechnologyRatherthanbeingadistinctdisease,hypertensionisanimportantbecomesmoresophisticatedandreadilyavailable,proteomicriskfactorforseveraldifferentcardiovascularconditions,includinganalysishasthepotentialtoplayaroleinclinicalpractice,incorona
8、ryarterydisease(CAD),renalfailureandstroke.Despiteitsidentifyingunderlyingpathophysiologicalcausesofhypertension,globalprevalence,thereremainmanyfactorsthatarepoorlyinindividualisi
