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accounting for the tongue-and-groove effect using a robust direct aperture optimization approach

accounting for the tongue-and-groove effect using a robust direct aperture optimization approach

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时间：2018-02-09

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1、Accountingforthetongue-and-grooveeffectusingarobustdirectapertureoptimizationapproachaEhsanSalariDepartmentofIndustrialandSystemsEngineering,UniversityofFlorida,Gainesville,Florida32611-6595ChunhuaMenDepartmentofRadiationOncology,UniversityofCaliforniaSanDiego,LaJ

2、olla,California92037-0843H.EdwinRomeijnDepartmentofIndustrialandOperationsEngineering,UniversityofMichigan,AnnArbor,Michigan48109-2117Received2August2010;revised4January2011;acceptedforpublication6January2011;published14February2011Purpose:Traditionally,thetongue

3、-and-grooveeffectduetothemultileafcollimatorarchitectureinintensity-modulatedradiationtherapyIMRThastypicallybeendeferredtotheleafsequencingstage.TheauthorsproposeanewdirectapertureoptimizationmethodforIMRTtreatmentplanningthatexplicitlyincorporatesdosecalculatio

4、ninaccuraciesduetothetongue-and-grooveeffectintothetreatmentplanoptimizationstage.Methods:Theauthorsavoidhavingtoaccuratelyestimatethedosimetriceffectsofthetongue-and-groovearchitecturebyusinglowerandupperboundsonthedosedistributiondeliveredtothepatient.Theythendev

5、elopamodelthatyieldsatreatmentplanthatisrobustwithrespecttothecorrespondingdosecalculationinaccuracies.Results:Testsonasetoftenclinicalhead-and-neckcancercasesdemonstratetheeffectivenessofthenewmethodindevelopingrobusttreatmentplanswithtightdosedistributionsintarge

6、tsandcriticalstructures.Thisiscontrastedwiththeverylooseboundsonthedosedistributionthatareobtainedbysolvingatraditionaltreatmentplanoptimizationmodelthatignorestongue-and-grooveeffectsinthetreatmentplanningstage.Conclusions:Arobustdirectapertureoptimizationapproach

7、isproposedtoaccountforthedosi-metricinaccuraciescausedbythetongue-and-grooveeffect.Theexperimentsvalidatetheabilityoftheproposedapproachindesigningrobusttreatmentplansregardlessoftheexactconsequencesofthetongue-and-groovearchitecture.©2011AmericanAssociationofPhysi

8、cistsinMedicine.DOI:10.1118/1.3547722Keywords:IMRTtreatmentplanning,aperturemodulation,tongue-and-grooveeffectI.INTRODUCTIONmentplanthatisclini

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