制药工程实验讲义-轻院

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1、实验须知制药工程专业实验是制药工程专业课程的重要组成部分，是使学生进一步理论联系实际，掌握仪器分析、药物合成、药物制剂、药物分析、药物分离工程等实验的基本操作技能，提高学生实际分析和解决问题能力。养成严密科学态度和良好工作作风必不可少的教学环节。为此，提出下列实验须知：1．遵守实验室制度，维护实验室安全，不违章操作，严防爆炸、着火、中毒、触电、漏水等事故的发生。若发生事故应立即报告指导教师。2．实验前作好预习，明确实验内容，了解实验的基本原理和方法，安排好当天计划，争取准时结束。实验过程应养成及时记录的习惯。凡是观察到的现象和结果及有关的重量、体积

2、、温度或其他数据，应立即如实记录，实验完毕后，认真总结，写好报告，交给老师。3．实验室中保持安静，不许大声喧嚷，不许抽烟、不迟到、不随便离开，实验台面应保持清洁，使用过的仪器及时清洗干净，存放在实验柜内，废弃的固体和滤纸等丢入废物缸内，绝不能丢入水槽、下水道和窗外，以免堵塞和影响环境卫生。4．药品仪器都是国家财产，须节约爱护使用，公用物品，用完后立即放回原处。不可调错瓶塞，以免污染，仪器要洗刷干净。破损仪器应填写破损报告单，注明原因。节约用水、用电、药用试剂。严格药品用量。5．操作易燃性有机溶剂，回流、蒸馏、减压蒸馏时，不能明火直接加热，要放沸石或

3、一端封死的毛细管，若在加热时发现无沸石则应冷却后再加，防止爆沸冲出。减压系统应装有安全瓶。加液时应停火或远离火源，一般无漏气开口，冷凝水要通畅。起封易挥发溶剂瓶盖时，脸面要避免开瓶口慢慢启开，以防气体冲脸上。6．有毒具腐蚀药品应妥善保管，操作后要立即洗手。勿粘及五官和创口，以免中毒。实验中，有毒气或腐蚀性气体发生适应在通风橱中进行操作。必要时可戴好防护用具进行工作。7．保持实验室内整洁，学生采取轮流值日，每次实验完毕，负责整理公用仪器，将实验台、地面打扫干净，倒清废物缸，检查门、窗、水、电、煤气是否关好。并清点仪器后方可离去。154实验目录实验一紫

4、外光谱技术及应用···················································································1实验二原子吸收技术及应用···················································································5实验三红外光谱技术及应用·············································································

5、······11实验四核磁共振波谱技术及应用···········································································14实验五气相色谱法操作技术和定性定量方法·······················································18实验六高效液相色谱操作技术和定性定量方法···················································28实验七扑热息痛的合成···················

6、········································································35实验八阿司匹林铝的合成·······················································································37实验九磺胺醋酰钠的合成·······················································································39实验十

7、盐酸普鲁卡因的合成···················································································42实验十一对氨基苯磺酰胺的合成···········································································45实验十二苯妥英钠的合成·················································································

8、······48实验十三安替比林的合成··········································