国际会议论文ppt.ppt

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1、IdiopathicAdultNephroticSyndrome:AClinicopathologicalStudyandResponsetoSteroidinaSub-SaharanAfricanCountryLiShuangDaiQingZhengWeiRepoerters:ContentIntroductionofNSPatientsandMethodsResultsDiscussionConclusionIdiopathicnephroticsyndrome(NS)isdeterminedbyaproteinuriahigherthan3g/

2、24hassociatedwithhypoalbuminemia,withnokidneyinflammatorylesionsorimmunecomplexdeposits.DefinitionClinicaltranslationpodocyteinjury25%-30%glomerulonephritisinadult50%ofglomerulonephritischronickidneydiseaseAimsofthestudyAEpidemiologyBClinico-biology.CHistologyDTherapeutics&Prog

3、ressionprofilePatientsteenyearsofageandaboveNephrologyDepartmentatAristideLeDantecUniversityHospitalduring2001.01to2010.10MethodsDescriptivestudyofdifferentvariablesBiveriatanalysisElectronicquestionnaireelaboratedbyEpiInfo3.3.2versionAnalysisDatacollectionPopulationdistributio

4、nResults(156outof202patientswereprimitive(77%)SymptomsLaboratorydetailsRenalbiopsyTreatmentsPrognosisAgethemeanagewas17.7-41.7yearsthegroupof15-25yearswasthemostrepresentativewith46％ofpatientsGendermenrepresented72％(112patients)womenrepresented28％(44patients)Populationdistribut

5、ionSymptoms40%63%hypertensionhypertensionwasfoundin63patients.edemaedemawasthemostfrequenttypeofpresentationfoundin98patients.Laboratorydetailsmeanserumprotein41.7-55.3g/lmeanserumalbumin10-30g/lmeanproteinuria2.2-11.4g/24hrenalinsufficiency44%(n=68)hypertriglyceridemia52.5%(n=

6、82)Renalbiopsytreatmentlifestylemeasuresdrugtreatmentsufficentcaloricdiet(100%)fluidrestriction(13.4%)sodiumrestriction(95%)alowpotassiumdiet(5.7%)diuretics(91.5%)antiproteinuricagents(43%)ACE-inhibitors(100%)anticoagulation(8.4%)steroid(95.9%)alone(85.8%)Steroidtherapywithcycl

7、ophosphamide(7.6%)withazathioprine(2.5%)Prognosiscompleteremissionpatialremissionrelapse23.7%4.45%5.1%Discussion1423PrevalenceAgeHistologyprogress77%41.2%12%Akpechi’sstudyDeme’studyPrevalenceofidiopathicNSourstudymeanageof29years02Ageourstudyagegroupof25-34yearsDeme’sstudyHisto

8、logyFSGS(局灶性节段性肾小球硬化)T.MN(微小病变型)MCD(膜性肾病)45.6%5%43.4%