最新[精品PPT]口腔粘膜溃疡类疾病-药学医学精品资料.ppt

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1、最新[精品PPT]口腔粘膜溃疡类疾病-药学医学精品资料IntroductionBehÇet’sdiseaseTraumaticUlcer&TraumaticBullaRecurrentAphthousUlcerSummary&QuestionsBACKReiter’sSyndromeI.IntroductionUlcersareoneofthemostcommontypesoflesionsseeninoralmucosa.2.Thedifferencebetweenulceranderosion.NEXT•T

2、ypingLehner’sclassificationminoraphthousulcer（MiAU）majoraphthousulcer（MjAU）herpetiformulcer（HU）•Characteristicrecidivityself-healingperiodicityNEXT2.Etiologyunknown•immunity:cellularimmunity,humoralimmunity,complement,autoantibody•heritage•infection：HSV•envi

3、ronment:psychologyNEXT•denutrition：iron,copper,zinc,folicacid,VitB12•hyperoxidedismutase•microcirculationdisturbance：lip,nail,apexlinguae•systemicfactor：ulcerationofstomach、hepatitis、colonitis、diarrhoeaNEXT3.Clinicalfeaturesminoraphthousulcermajoraphthousulc

4、erherpetiformulcerNEXTNEXTMiAUMjAUHUfeatureyellowredconcavepainfulsmall(2-4mm)big(1-3cm)deepscarmultiplesmallcourse7-10days3-6weeks7-10daysnumber1-51>10positionnonkeratinizedoralmucosasoftpalatetonguelipmouthfloorsystemicsymptom—lymphnodesswellingfeverheadac

5、helymphnodesswellingMinoraphthousulcersNEXTNEXTNEXTMiAUMjAUHUfeatureyellowredconcavepainfulsmall(2-4mm)big(1-3cm)deepscarmultiplesmallcourse7-10days3-6weeks7-10daysnumber1-51>10positionnonkeratinizedoralmucosasoftpalatetonguelipmouthfloorsystemicsymptom—lymp

6、hnodesswellingfeverheadachelymphnodesswellingMajoraphthousulcersNEXTPeriadenitisMucosaNecroticaRecurrensNEXTMajoraphthousulcersNEXTMiAUMjAUHUfeatureyellowredconcavepainfulsmall(2-4mm)big(1-3cm)deepscarmultiplesmallcourse7-10days3-6weeks7-10daysnumber1-51>10p

7、ositionnonkeratinizedoralmucosasoftpalatetonguelipmouthfloorsystemicsymptom—lymphnodesswellingfeverheadachelymphnodesswellingHerpetiformulcersNEXTdisease-process24h10d-14doutbreakNEXTintermissionhealingprodromalstageulcerativestage5.Diagnosishistoryclinicalf

8、eatureNEXT4.Pathology：nonspecificinflammation6.Differentialdiagnosisbenignulcer&malignantulcerNecrotizingsialadenometaplasia,Behçet’sdisease,herpessimplex,hand-foot-and-mouthdiseaseNEXTbenignulc