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1、X-RayCrystalStructureofSykTyrosineKinaseRegulatorySH2ResearchSummaryPyrrolinoneb-StrandPeptidomimeticHIV-1ProteaseInhibitor1999-presentUPennb-SheetSandwich1998-1999UCIrvineCycloadditionofEnolEthers1994-1998UCLAEnantioselectiveEpoxidationPartIComputationalStudyonEpoxidationReactionsb.Confo
2、rmationalSwitchforEnolEthersinCycloadditionReactionsConformationalSwitchinCycloaddition ofEnolEtherss-cisingroundstates-transintransitionstateLiu,J.;Niwayama,S.;You,Y.;Houk,K.N.J.Org.Chem.1998,63,1064.StereoselectiveCycloadditionReactionsof ChiralEnolEtherDenmark,S.E.et.al.J.Org.Chem.1994
3、,59,5672;1995,60,3205;1995,60,3574.Reissig,H.U.et.al.SYNLETT1990,514;Angew.Chem.Int.Ed.Engl.1992,31,1033.GroundStateConformationsofChiralEnolEthersConformationsofVinylMethylEtherinGroundandTransitionStatesDesignofConformationFixedEnolEtherstranscistranscisDesignedDiels-AlderReactionswitht
4、heConformationFixedEnolEthersDesigned1,3-dipolarCycloadditionWiththeConformationFixedEnolEthersComparisonoftheCalculatedandExperimentalResultsRationalizationofConformationSwitchSummaryforPh.DResearchatUCLAa.Computationstudyonepoxidationreaction:b.Conformationswitchofenoletherincycloadditi
5、onreaction:PartIIDesign,SynthesisandStructureStudyofArtificialb-SheetSandwichesPreviousStudyonArtificialb-SheetStructuresNowick,J.S.etalJ.Org.Chem.1997,62,7906-7907.Nowick,J.S.etalChem.Soc.Rev.1996,25,401-415.Nowick,J.S.Acc.Chem.Res.1999,32,287-296.TheImportanceoftheb-SheetSandwichinNatur
6、eDefinition:Theb-Sheetsandwichisastructuremotifinproteinsinwhichtwob-sheetsfaceeachothertoformasandwich.Theb-sheetsandwichcanactasabindingpocket.Goalofbuildingtheartificialb-sheetsandwich:Tobuildachemicalmodeltomimicthethreedimensionalstructuresofglobularproteins.Lipidbindingprotein:1lifD
7、esignofanArtificialb-SheetSandwichHydrophilicBackHydrophobicFaceSynthesisofaModelwithoneTemplate Holdingtwob-TurnScaffoldStructuresSynthesisofaModelwithOneTemplate HoldingTwob-TurnScaffoldStructures(Cont.)CrystalStructureoftheModelwithaTemplateHoldingTwob-TurnScaffo
