最新Identification of a Ninth Foot-and-Mouth Disease Virus Type O 教学讲义PPT课件.ppt

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1、IdentificationofaNinthFoot-and-MouthDiseaseVirusTypeOFMDVOinAfricaWRLFMDIAHPreviousstudiesFewstudiesontheEuropeanFMDVserotypesinAfrica:Knowlesetal.,1998(typeA)Samueletal.,1999(typeO)Samuel&Knowles,2001(typeO)Sangareetal.,2001(typeO)Sahleetal.,2004(typeO)Bronsvo

2、ortetal.,2004(typesO&A)DistinctgeneticlineagesofbothFMDV-OandFMDV-AcirculateinEastandWestAfricaandvirusesoccurringinNorthAfricamaybeintroducedfromavarietyofsources(Europe,SouthAmerica,MiddleEastandWestAfrica).OutbreaksofFMDtypesOandAinsouthernAfricaareveryrarea

3、ndareusuallyintroducedfromoutsidethecontinent.WRLFMDIAHVP1(145-642)WRLFMDIAHVP1(478-642)WRLFMDIAHScanninganalysisofVP1WRLFMDIAHScanninganalysisofVP1WRLFMDIAHOccurrenceofFMDVOTopotypesinAfricaWRLFMDIAHFMDVOTopotypes-20041%O/A/CHA/58O1/Manisa/TUR/69O/ALG/1/99O/CI

4、V/8/99O/GHA/5/93O/KEN/83/79O/KEN/2/95O/UGA/5/96O/BUN/7/2003O/KEN/5/2002O/KEN/7/2002O/KEN/3/2002O/UGA/3/2002O/MAL/1/98O/TAN/7/98O1/Kaufbeuren/FRG/66O3/VEN/51O2/Brescia/ITL/47O/ISA/1/74O/JAV/5/72O/ISA/1/62O/ISA/9/74O/ISA/8/83O/HKN/14/82O/PHI/7/96O/TAW/81/97O/CAM/

5、2/98O/VIT/7/97O/TAI/4/99O/IRQ/30/2000EastAfrica1(EA-1)WestAfrica(WA)MiddleEast-SouthAsia(ME-SA)South-eastAsia(SEA)Europe-SouthAmerica(Euro-SA)Indonesia-2(ISA-2)Indonesia-1(ISA-1)CathayEastAfrica2(EA-2)WRLFMDIAHFutureworkWearecompletingthecompletecapsidsequencin

6、gof9AfricanFMDVOisolatesincludingrepresentativesofallindigenoustopotypesWehaveanon-goingstudyofFMDVOinAfricaWehavecompletedastudyofFMDVAinAfrica(~80VP1sequences)IAHConclusionsTwopreviouslyunrecognisedgeneticlineagesofFMDVOwereidentifiedinEastAfrica,eachhavingad

7、istinctgeographicdistribution.Recombinationnearthe3’endofVP1mayhaveplayedaroleintheevolutionoftheEA-2topotype.Alternatively,itmaybethatalltheAfricanlineagesevolvedaftertheintroductionofAsianFMDvirusesintoAfricaandmoremutationshavesubsequentlyaccumulatedincertai

8、npartsofthecapsid-codingregionwhileotherpartsmayhaveremainedmoreconserved.WRLFMDIAHRecommendationsFuturephylogeneticanalysesformolecularepidemiologicalpurposesshouldbebasedo