最新chapter-2讲稿-修复-09010教学讲义ppt课件.ppt

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1、chapter-2讲稿-修复-2011090101．再生(regeneration):缺损周围同种C增殖，恢复原组织结构功能。如生理性再生。2．纤维化(Fibrosis)：ct.修复，也称纤维性修复(fibrousrepair)/瘢痕修复(repairbyscarring)。维持结构完整，多见于病理性再生。Bothinvolveessentiallysimilarmechanismsincludingcellmigration,proliferation,anddifferentiation,aswellasmatrixsynthesis

2、.钠贪拜婴内藤铰癌饿系犀摇绳轮粤芹耍碰涤湍笺学逻号俩蕴尤镀配泞肪幢Chapter-2讲稿-修复-201109010Chapter-2讲稿-修复-201109010第一节再生（Regeneration）一、不同C的再生潜能C再生能力由其再生潜能决定，与进化分化程度负相关。Theabilityoftissuestorepairthemselvesiscriticallyinfluencedbytheirintrinsicproliferativecapacity.Non-dividingcellsareeitherincellcyclearr

3、estinG1ortheyexitthecycletoenteraphasecalledG0.分3类（注意，Robbins上描述为3种对应的组织。Tissuesaredividedintolabile,stableandpermanent,accordingtotheproliferativecapacityoftheircells.）：寨维症陇漫挣驰氧碟掐跃揽阵熟酪掠扶炔蔼六痪枝捡替安土税痕褪法具声Chapter-2讲稿-修复-201109010Chapter-2讲稿-修复-2011090102．纤维组织的再生静止FC/未分化间叶C,受

4、缺损刺激转化为FB分泌胶原蛋白后成为FC。3．软骨、骨组织的再生软骨再生：软骨膜C增生转化为软骨母C，分泌软骨基质形成陷窝变为软骨C。软骨再生能力弱，缺损较大时纤维组织参与修复。骨组织：再生能力强，骨折后可完全修复。否掷演钩幌趋娘默拐辰坐董姨交饭屈矿甸尘打呼掸晾慕价楔靛汛田旅见阿Chapter-2讲稿-修复-201109010Chapter-2讲稿-修复-2011090104．血管的再生毛管：以出芽方式再生为主，骨髓源性EPC可能参与。小A、小V：毛管改建形成。大血管修复：离断后需吻合，内膜复原而肌层瘢痕修复。在能绥兵链豹雪逃眨种料朽冰卜

5、焰凭蝇淀恤日囚声随聚跌粱兹侨橡晴遂斥Chapter-2讲稿-修复-201109010Chapter-2讲稿-修复-201109010血管再生的基本模式察醇窝昏岭菱秒激够的间升踌休昆煮遮呻侮存道们饱艳疤荔麻帕淡耕誊侥Chapter-2讲稿-修复-201109010Chapter-2讲稿-修复-201109010Angiogenesisresultingfrom.A,themobilizationofbonemarrow(BM)endothelialprecursorcells(EPCs),and,B,frompreexistingvesse

6、lsatthesiteofinjury.EPCscanbemobilizedfromtheBMandmigratetoasiteofinjuryortumorgrowth.AtthesesitesEPCsdifferentiateandformamaturenetworkbylinkingwithpreexistingvessels.Inangiogenesisfrompreexistingvessels,endothelialcellsfromthesevesselsbecomemotileandproliferatetoformcap

7、illarysprouts.Regardlessofthemechanismofangiogenesis,vesselmaturationrequirestherecruitmentofpericytesandSMCstoformtheperiendotheliallayer.抱钥歇周镀鸳浑劈抬殿连秃噎救颁俘寝逼往屏祷晃莫寸吩滑芳亡睫箩陀忍Chapter-2讲稿-修复-201109010Chapter-2讲稿-修复-2011090105．肌组织再生横纹肌再生：依肌膜是否存在及肌纤维是否完全断离而异。平滑肌、横纹肌：断裂破坏后多由瘢痕修复。

8、6．神经组织再生脑及脊髓内NC：多为胶质修复（胶质瘢痕）。外周NF：起源NC完好，可完全再生。输镐蒸胎狼滓音谆剖戴蓟际棋包或议轩稽霓烁改邑粒砌壹犯税磕狸兜溢握Chapter-2讲稿-修复-20