假阿洪病一例.docx

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1、钙泊三醇外用治疗可减少银屑病皮损中ICAM-3阳性浸润细胞的表达钙泊三醇外用治疗可减少银屑病皮损中ICAM-3阳性浸润细胞的表达中华皮肤科杂志1998年第6期第31卷论著作者：蔡绥勍　郑敏　孙国均单位：杭州，浙江医科大学附属第二医院皮肤科关键词：银屑病；钙泊三醇；胞间粘附分子【摘要】　目的　了解钙泊三醇局部外用治疗对银屑病皮损中细胞间粘附分子3(ICAM-3)表达的影响。方法　采用ABC免疫组化法对20例银屑病患者皮损与非皮损部位以及皮损部位治疗前后的ICAM-3、Ki-67和其它免疫分子的表达进行了研究。结果　银屑病皮损部位ICAM-3阳性浸润细

2、胞的表达均明显高于非皮损部位及正常对照组(P均＜0.01)，而且ICAM-3的表达和皮损部位Ki-67、CD3等免疫分子的表达呈正相关。经钙泊三醇外用治疗6周后，皮损部位ICAM-3、Ki-67和CD3的表达均明显减少(P均＜0.01)。结论　外用钙泊三醇治疗银屑病的机制除了有抗角朊细胞增殖的作用外，对可能参与银屑病发病机制的ICAM-3阳性浸润细胞也有作用。TopicalTreatmentofCalcipotriolDecreasesExpressionofICAM-3PositiveInfiltratingLeukocytesinPsoriat

3、icSkinCaiSuiqing,ZhengMin,SunGuojun.DepartmentofDermatology,theSecondAffiliatedHospitalofZhejiangMedicalUniversity,Hangzhou【Abstract】　Objective　TostudytheeffectoftopicalcalcipotrioltreatmentontheexpressionofICAM-3moleculeininfiltratingleukocytesofskinlesionsofpatientswithpsori

4、asisbeforeandaftertreatment.Methods　ExpressionofICAM-3,Ki-67andCD3wasstudiedintheskinbiopsiesfrom20patientswithchronicplaquetypepsoriasisbeforeandaftertopicalcalcipotrioltreatmentbyusinganimmunohistochemicaltechnique?AvidinBiotinComplex(ABC)System.Results　ICAM-3,Ki-67andCD3pos

5、itivestainingcellsintheskinlesionsweresignificantlyhigherthanthoseinuninvolvedskinaswellasthoseofnormalcontrols,andtherewasapositivecorrelationbetweenthelesionalexpressionofICAM-3andKi-67molecules,aswellasbetweenlesionalexpressionofICAM-3andCD3molecules.Aftersixweeksoftopicala

6、pplicationwithcacipotriol,theexpressionofICAM-3,Ki-67andCD3ininvolvedskinweresignificantdecreased(P＜0.01).Conclusion　Itisindicatedthatthe,mechanismoftopicaltreatmentwithcalcipotriolinpsoriasisinvolvesnotonlyinhibitingkeratinocyteproliferation,butalsoeffectingICAM-3positiveinfi

7、ltratingleukocytesinlesionalskin,whichmaybeinvolvedinthepathogenesisofpsoriasis.【Keywords】　Psoriasis　Calcipotriol　Intercellularadhesionmolecule细胞间粘附分子3(ICAM-3)是一种免疫球蛋白超基因家族的成员，与淋巴细胞功能相关抗原1(LFA-1)互为配受体，我们已报道ICAM-3在银屑病皮损部位表达异常增高。银屑病作为一种以表皮角朊细胞过度增殖和炎症细胞浸润为特征的慢性炎症性皮肤病，其治疗方法有多种，钙泊三

8、醇是治疗银屑病的一种外用新药，其抗病机理许多国外学者已进行了研究。现在我们采用免疫组化方法，观察外用钙泊三醇治疗对银屑病皮