美国著名高血压教授简介 Mohan K. Raizada Ph.D.(英文).ppt

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1、AboutMohanK.Raizada,Ph.D.HuaFuDepartmentofCardiorenalandCerebrovascularMedicine,KagawaUniversitySchoolofMedicineQ：279486524MohanK.Raizada,Ph.D.DistinguishedProfessorMemberoftheMcKnightBrainInstituteMemberofTheNeurogenicCardiovascularDiseasesConsortiumMohanK.Raizada,Ph.D.Dr.Raiza

2、dahasbeenabiomedicalresearcherandeducatorfor25years. HereceivedhisPh.DfromtheUniversityofKanpur,IndiaandperformeddissertationresearchattheCentralDrugResearchInstitute,India.Dr.RaizadajoinedtheDepartmentofPhysiologyandBiophysics,UniversityofIowaasanassistantprofessorin1979. Hemov

3、edtotheUniversityofFloridain1981asanassociateprofessorwhereheiscurrentlyaDistinguishedProfessorofPhysiologyandFunctionalGenomics.Dr.Raizadaisaleaderinthefieldofneuralcontrolofcardiovascularfunctionsandhaspioneeredphysiologicalgenomictechniquestoinvestigatetheinvolvementofthereni

4、n-angiotensinsystemincardiopulmonarydisease.Hismostsignificantcontributionhasbeenthedemonstrationthatangiotensinconvertingenzyme2(ACE2)andvasoprotectiveaxisoftheRASplaysacriticalroleinmaintaininganormalcardiovascularhomeostasis,andispoisedtobeabettertherapeutictargetforthenextge

5、nerationofantihypertensives.Dr.Raizadahaspublished210peer-reviewedpapers,55reviewarticles,editedtenbooks,andhasbeenandcontinuestobeaninvitedspeakeratnationalandinternationalmeetings.ResearchInterestsProject1:MechanismsofNeurogenicHypertensionProject2:PotentialofACE2-Angiotensin-

6、(1-7)axisoftheRASasatargetforthecontrolofpulmonaryhypertension(PH)andCVDProject3:Genetically-modifiedstemcellsforPHandCVDtherapeuticsNeurogenicHypertensionJMolNeurosci(2007)33:284–293CurrHypertensRep.2010August;12(4):212–219.TargetingtheACE2/Ang-(1-7)/Masaxispreventsandreversesp

7、ulmonaryvascularpathologyofpulmonaryarterialhypertension.ACE—angiotensin-convertingenzyme;AngII—angiotensinII;AT1R—angiotensinIItype1receptor;AT2R—angiotensinIItype2receptor;BMPR-II—bonemorphogeneticproteinreceptortypeII;ERK1/2—extracellularsignal-regulatedproteinkinase1/2;NO—ni

8、tricoxide;TGF-β—transforminggrowthfactorβCurrHy