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1、Theoptimaldistancebetweentwoelectrodetipsduringrecordingofcompoundnerveaction potentialsintheratmediannerveYongpingLi1,2,JieLao1,XinZhao1,DongTian1,YiZhu1,XiaochunWei21DepartmentofHandSurgeryofHuaShanHospital,FudanUniversity;KeyLaboratoryofHandReconstruction,MinistryofHealthy;ShanghaiKeyLa
2、boratoryofPeripheralNerveandMicrosurgery, Shanghai,China2DepartmentofOrthopedics,theSecondHospitalofShanxiMedicalUniversity,Taiyuan,ShanxiProvince,China窗体顶端Abstract:Thedistancebetweenthetwoelectrodetipscangreatlyinfluencetheparametersusedforrecordingcompoundnerveactionpotentials.Toinvestig
3、atetheoptimalparametersfortheserecordingsintheratmediannerve,wedissociatedthenerveusingdifferentmethodsandcompoundnerveactionpotentialswereorthodromicallyorantidromicallyrecordedwithdifferentelectrodespacings.Compoundnerveactionpotentialscouldbeconsistentlyrecordedusingamethodinwhichthemid
4、dlepartofthemediannervewasintact,withbothendsdissociatedfromthesurroundingfasciaandagroundwireinsertedintothemuscleclosetotheintactpart.Whenthedistancebetweentwostimulatingelectrodetipswasincreased,thethresholdandsupramaximalstimulatingintensityofcompoundnerveactionpotentialsweregraduallyd
5、ecreased,buttheamplitudewasnotchangedsignificantly.Whenthedistancebetweentworecordingelectrodetipswasincreased,theamplitudewasgraduallyincreased,butthethresholdandsupramaximalstimulatingintensityexhibitednosignificantchange.Differentdistancesbetweenrecordingandstimulatingsitesdidnotproduce
6、significanteffectsontheaforementionedparameters.Adistanceof5mmbetween recordingandstimulatingelectrodesandadistanceof10mmbetweenrecordingandstimulatingsiteswerefoundtobeoptimalforcompoundnerveactionpotentialrecordingintheratmediannerve.Inaddition,theorthodromiccompoundactionpotential,witha
7、biphasicwaveformthatwasmorestableanddisplayedlessinterference(howeveralsorequiredahigherthresholdandhighersupramaximalstimulus),wasfoundtobesuperiortotheantidromiccompoundactionpotential.Keywords：nerveregeneration;peripheralnerveinjury;compoundnerveactionpoten
