肿瘤干细胞-分子诊断与靶向治疗说课材料.ppt

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1、肿瘤干细胞-分子诊断与靶向治疗1.Whatarecancerstemcells(CSC)?aselectivelyendowedtumori-geniccapacitytorecreatethefullrepertoireofcancercellsoftheparentaltumortheexpressionofadistinctiverepertoireofsurfacebiomarkers2.Whyisresearchoncancerstemcellsimportant?weedweedrootcancercanc

2、ercancercancer---Noprairiefirecandestroythegrass,itshootsupagainwiththespringbreezeblows.cancerstemcells3.Inwhattumortypeshavecancerstemcellsbeenidentified?LeukemiaStemCellsBreastCancerStemCellsHeadandNeckCancerStemCellsAdrenalCancerStemCellsPancreaticCancerStem

3、CellsLung,melanoma,myeloma,prostateandthyroidcancers...4.Howarecancerstemcellsidentified?Table1Examplesofnon-carbohydratestemcellmarkerswhicharealsocancerstemcellmarkers5.Whathappensafterstemcellsareidentified?howcancerstemcellsworkidentifydrugsthatwillkillthest

4、emcellswithoutharmingnormalcells.CancerStemCellResearchProgramGoal1.Toinvestigatepotentialpathwayscriticalforselfrenewal,spreadandsurvivalofnormalandcancerstemcells.Goal2.Todevelopnewtherapiesdirectedagainstcancerstemcells.6.Areclinicaltreatmentsavailablenowtota

5、rgetcancerstemcells?earlystagesInitialresultsarepositiveadditionaltrialsinalargernumberofpatientswillbenecessary6.2Figure1Oxaliplatin-incorporatingmicellesareeffectivefortheeradicationofcancerstemcells(CSCs).Abbreviations:CSO,chitosanoligosaccharideSA,stearicaci

6、dDevelopmentofnanomedicineforCSCs——Drug-deliverysystemsforCSCs6.1Strategiesforstemcell-basedantibodytherapyofcancerFigure.Modelofpotentialstrategiesfortheuseofstemcellsinantibodytherapy6.3iPSCs:Inducedpluripotentstemcells6.4PotentialapplicationsofhumaniPSCsforli

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