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1、“非诚勿扰”与恶性黑色素瘤catalogueWhatismalignantmelanoma?MelanomatriggersandcausesPrimarysitesClinicalcharacteristicsEarlyclinicalperformanceLate-stageclinicalmanifestationsPathologicaltypeTreatment2010melanomafieldprogressreviewWhatismalignantmelanoma?Malignantmelanoma,alsoknownasmelanoma,isthe
2、originofepidermalmelanocyteornevusofmalignanttumors. Thediseasecanbeseenatanyage,moreseeninmiddle-agedandolder,womenslightlymorethanmen.MelanomatriggersandcausesAirpollutionTopursuebeautyThelackofmedicineknowledgeImmunedeficiencyAbusingtheestrogendrugsMalignanttransformationofblackmol
3、eRacialgeneticfactorsTraumaandchronicstimulationfactorsAirpollutionHarmfulultravioletlightandsomeharmfulmaterialintheairmakeadifferenceofhumanskin,causingmelanocyteabnormalexpression,triggermelanoma.Manypeopleinordertopursuethecleanskintousechemicalcosmetics,skinpollutioncausedbychemi
4、cal,evensomeonewithchemicalmordantpurifyskinamole,stimulatestheexcessiveproliferationmelanocyte.TopursuebeautyRacialgeneticfactorsMalignantmelanomaoccurinthewhiterace.Fortheincidenceofworldeachyeartolessthan1~2/10million,butAustralia'sQueenslandannualincidenceof16/10millionpopulation,
5、itistheworld‘sleadinghighincidenceofmalignantmelanoma.AfricaandAsianpeoplerarelyhavethesickness.PrimarysitesMalignantmelanoma90%occursintheskin,themostcommonintheback,metal-studded,leg,foot,toe,nailbed,scalpandsoon;afewoccursinvulvae,digestivetractandeyes.Eyelesions andOrallesions脉络膜黑
6、色素瘤口腔黑色素瘤◆Generallyspeakingmolessurfaceissmooth,melanomaofsurfaceiscoarser.Ifthesurfaceissmooth,andsuddenlybecomescoarseor,weshouldpayattentiontoit.Clinicalcharacteristics◆Ulcerationnotonlyisoneoftheimportantmelanomaclinicalmanifestationswhichisdifferentfrommole,butalsohasthemeaningof
7、prognosisthannoulcer.◆Patientsofmalignantmelanomagenerallyaretheold;theyouthorchildrenmelanomaarerare.EarlyclinicalperformanceColor:amoleincreaseinsize,pigmentordarkerorlighter,amoledeepen,shiny,appearcolorchanged.Edge:amoletoradiateoutinmolesexpansion,appeararoundunevenindentedchange
8、;beco
