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1、“非诚勿扰”与恶性黑色素瘤catalogueWhatismalignantmelanoma?MelanomatriggersandcausesPrimarysitesClinicalcharacteristicsEarlyclinicalperformanceLate-stageclinicalmanifestationsPathologicaltypeTreatment2010melanomafieldprogressreviewWhatismalignantmelanoma?Malignantmelanoma,alsoknownasmelanoma,istheorig
2、inofepidermalmelanocyteornevusofmalignanttumors. Thediseasecanbeseenatanyage,moreseeninmiddle-agedandolder,womenslightlymorethanmen.MelanomatriggersandcausesAirpollutionTopursuebeautyThelackofmedicineknowledgeImmunedeficiencyAbusingtheestrogendrugsMalignanttransformationofblackmoleRacialg
3、eneticfactorsTraumaandchronicstimulationfactorsAirpollutionHarmfulultravioletlightandsomeharmfulmaterialintheairmakeadifferenceofhumanskin,causingmelanocyteabnormalexpression,triggermelanoma.Manypeopleinordertopursuethecleanskintousechemicalcosmetics,skinpollutioncausedbychemical,evensome
4、onewithchemicalmordantpurifyskinamole,stimulatestheexcessiveproliferationmelanocyte.TopursuebeautyRacialgeneticfactorsMalignantmelanomaoccurinthewhiterace.Fortheincidenceofworldeachyeartolessthan1~2/10million,butAustralia'sQueenslandannualincidenceof16/10millionpopulation,itistheworld‘sle
5、adinghighincidenceofmalignantmelanoma.AfricaandAsianpeoplerarelyhavethesickness.PrimarysitesMalignantmelanoma90%occursintheskin,themostcommonintheback,metal-studded,leg,foot,toe,nailbed,scalpandsoon;afewoccursinvulvae,digestivetractandeyes.Eyelesions andOrallesions脉络膜黑色素瘤口腔黑色素瘤◆Generallys
6、peakingmolessurfaceissmooth,melanomaofsurfaceiscoarser.Ifthesurfaceissmooth,andsuddenlybecomescoarseor,weshouldpayattentiontoit.Clinicalcharacteristics◆Ulcerationnotonlyisoneoftheimportantmelanomaclinicalmanifestationswhichisdifferentfrommole,butalsohasthemeaningofprognosisthannoulcer.◆Pa
7、tientsofmalignantmelanomagenerallyaretheold;theyouthorchildrenmelanomaarerare.EarlyclinicalperformanceColor:amoleincreaseinsize,pigmentordarkerorlighter,amoledeepen,shiny,appearcolorchanged.Edge:amoletoradiateoutinmolesexpansion,appeararoundunevenindentedchange;beco
