博士生课程固有免疫模式识别ppt课件.ppt

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1、InnateImmunitymonocytemacrophagebacteriaThemostancientdefensePhysical&chemicalbarriersandcellularlineRecognitionbytheinnateimmunesystemsetsthestageforaneffectiveadaptiveimmuneresponse.机体在种系发生和进化过程中逐渐形成的一种天然免疫防御功能，构成机体抵御病原生物入侵的第一道防线.复习一、固有免疫系统的组成屏障细胞分子皮肤黏

2、膜屏障：物理、化学、微生物血-脑屏障、血-胸腺屏障血-胎屏障、气-血屏障单核-巨噬细胞、中性粒细胞、树突状细胞、γδT细胞、NK细胞、NKT细胞、B1细胞、肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞等。抗菌肽、溶菌酶、急性期蛋白、补体、细胞因子和黏附分子、Physical,chemicalandmicrobiologicalbarriersofourbody1、固有免疫屏障ThismaycauseinflammationandbleedingNormalFloracompetingwithInvadingPa

3、thogens.Antibiotictreatmentsdisruptthenaturalecologyofthecolon2、固有免疫细胞PhagocyteNKILLs（固有样淋巴细胞）DCMCBasophilEosinophilT细胞NKT细胞B1细胞Monocyte-macrophageNeutrophilRecognitionofaninfectiononceitgetspasttheepithelialbarrierPolarizationofTumor-associatedmacroph

4、ages(TAM)分泌IL-1IL-6IL-12TNF-aIL-8GM-CSF细胞因子酶其它因子杀伤肿瘤细胞抗原呈递作用前列腺素白三烯补体成分纤维蛋白结合蛋白凝血因子溶菌酶酸性水解酶赖氨酸酶酯酶胶原蛋白酶弹性纤维蛋白酶免疫调节作用吞噬并杀伤病原微生物巨噬细胞的功能Figure8-19part2of2Leukocyterecruitmenttositesofinfection:amulti-stepnavigation1.Selectins2.Chemokines3.IntegrinsIL-8Intera

5、ctionbetweenNeutrophilsandEndotheliumCellularAdhesionMolecules(CAMs):Mucin-likeCAMsSelectinsIntegrinsIg-superfamilyCAMsKilleractivatoryreceptorKillerinhibitoryreceptorKIR:KIR2DS,KIR3DSKLR:CD94/NKG2CNKG2DNKp46NKp30NKp44NCRKIR2DL,KIR3DLCD94/NKG2ABindclassI

6、HLAmoleculesFunctionBindnon-classIHLAmoleculesReceptorsassociatedwithkilleractivationandkillerinhibitiononNKcells2、固有免疫细胞PhagocyteNKILLs（固有样淋巴细胞）DCMCBasophilEosinophilT细胞NKT细胞B1细胞Monocyte-macrophageNeutrophil过敏性疾病抗原的处理与提呈Nuocytesrepresentanewinnateeff

7、ectorleukocytethatmediatestype-2immunity.Nature.2010Mar3.Type-2immunity:responsibleforprotectiveimmuneresponsestohelminthparasitesandtheunderlyingcauseofthepathogenesisofallergicasthma.Type-2cytokines:interleukinIL-4,IL-5andIL-13.Nuocytesexpandinvivoinre

8、sponsetothetype-2-inducingcytokinesIL-25andIL-33,andrepresentthepredominantearlysourceofIL-13duringhelminthinfection.InthecombinedabsenceofIL-25andIL-33signalling,nuocytesfailtoexpand,resultinginaseveredefectinwormexpulsio