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1、feverYu-HongJia,Ph.DDepartmentofpathophysiologyDalianmedicaluniversityFeverisacomplicatedpathologicalprocesscharacterizedbyaregulatedelevationofcorebodytemperature,inwhichthehypothalamicsetpointistemporarilyresetatanelevatedtemperatureinresponsetopyre
2、ticsubstances.ConceptoffeverT>37℃T<37℃thermostasisHeatloss(sweetgland,respiration,bloodvesselofskin)Heatproduction(skeletalmuscle,liver,thyroid,adrenalgland)ThermoregulatorycenterInhypothalamusSetpoint37℃thermoreceptorAfferentNEfferentNEfferentNNormal
3、thermoregulationFeverand↑corebodytemperaturefever→↑corebodytemperature↑corebodytemperature→feverhyperthermia:minority(bodytemperature>setpoint)PhysiologicalbodytemperatureelevationPathologicalbodytemperatureelevationfever:majority(bodytemperature=setp
4、oint)↑corebodytemperature(>0.5℃)·PhysiologicalbodytemperatureelevationNormalbodytemperature:37oC(setpoint,SP)Thedifferenceamongdifferentpartofbody:rectum(36.9~37.9C)>oral(36.7~37.7C)>armpit(36~37.4C)Differencebetweendayandnight<1C:bodytemperaturei
5、nafternoon>inmorningDifferencebetweenindividual<1C:young>oldPhysiologicalbodytemperatureelevationSevereexercise,dining,beforemenstruation,duringpregnancy→bodytemperatureincreaseslightlybodytemperatureexceedthelevelofsetpointPassiveelevationofbodytemp
6、erature(>0.5℃)excessivethermogenesisImpairmentofheat-lossDysfunctionofthermoregulatorycenterHyperthermiahyperthermiaconcept:hyperthermiaisdescribedastheelevationofbodytemperaturethatoccurswithoutchangesofthesetpointinthehypothalamicthermoregulatorycen
7、ter.Seenin:DysfunctionofthermoregulatorycenterHeatstrokeduetoichthyosisofskinorenvironmentalhightemperaturehyperthyroidismcomparisionbetweenfeverandhyperthermiafeverhyperthermiaDuetoeffectofpyrogenSetpointuppershiftThermoregulatoryfunctionisnormalBody
8、temperatureisequaltothelevelofsetpointRegulatedelevationofbodytemperatureActiveelevationofbodytemperatureInfectionofmicroorganism,tumorNopyrogen’seffectSetpointnormalDysfunctionofthermoregulatorycenter,dysfunctionofheatproductionorganofheatlos
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