发热英文课件.ppt

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1、feverYu-HongJia,Ph.DDepartmentofpathophysiologyDalianmedicaluniversityFeverisacomplicatedpathologicalprocesscharacterizedbyaregulatedelevationofcorebodytemperature,inwhichthehypothalamicsetpointistemporarilyresetatanelevatedtemperatureinresponsetopyre

2、ticsubstances.ConceptoffeverT>37℃T<37℃thermostasisHeatloss（sweetgland,respiration,bloodvesselofskin）Heatproduction（skeletalmuscle,liver,thyroid,adrenalgland）ThermoregulatorycenterInhypothalamusSetpoint37℃thermoreceptorAfferentNEfferentNEfferentNNormal

3、thermoregulationFeverand↑corebodytemperaturefever→↑corebodytemperature↑corebodytemperature→feverhyperthermia：minority(bodytemperature>setpoint)PhysiologicalbodytemperatureelevationPathologicalbodytemperatureelevationfever:majority(bodytemperature＝setp

4、oint)↑corebodytemperature(>0.5℃)·PhysiologicalbodytemperatureelevationNormalbodytemperature:37oC(setpoint,SP)Thedifferenceamongdifferentpartofbody:rectum（36.9～37.9C）>oral（36.7～37.7C）>armpit（36～37.4C）Differencebetweendayandnight<1C：bodytemperaturei

5、nafternoon>inmorningDifferencebetweenindividual<1C：young>oldPhysiologicalbodytemperatureelevationSevereexercise,dining,beforemenstruation,duringpregnancy→bodytemperatureincreaseslightlybodytemperatureexceedthelevelofsetpointPassiveelevationofbodytemp

6、erature(>0.5℃)excessivethermogenesisImpairmentofheat-lossDysfunctionofthermoregulatorycenterHyperthermiahyperthermiaconcept：hyperthermiaisdescribedastheelevationofbodytemperaturethatoccurswithoutchangesofthesetpointinthehypothalamicthermoregulatorycen

7、ter.Seenin：DysfunctionofthermoregulatorycenterHeatstrokeduetoichthyosisofskinorenvironmentalhightemperaturehyperthyroidismcomparisionbetweenfeverandhyperthermiafeverhyperthermiaDuetoeffectofpyrogenSetpointuppershiftThermoregulatoryfunctionisnormalBody

8、temperatureisequaltothelevelofsetpointRegulatedelevationofbodytemperatureActiveelevationofbodytemperatureInfectionofmicroorganism,tumorNopyrogen’seffectSetpointnormalDysfunctionofthermoregulatorycenter,dysfunctionofheatproductionorganofheatlos